UFT: Mechanism of Drug ActionByClaus Henning Köhne, MD,Godefridus J. Peters, PhDOctober 1st 2000The mechanism of action of fluorouracil (5-FU) and the oral fluoropyrimidines and the importance of biochemical modulation and inhibition of dihydropyrimidine dehydrogenase for oral application of the prodrugs of 5-FU are discussed.