Maryann Redlinger, RN | Authors

Irinotecan and UFT/Leucovorin in Patients With Advanced Cancers

October 01, 2000

The combination of irinotecan and fluorouracil (5-FU) is synergistic when applied to human colon cancer cell lines in vitro and appears to be schedule-dependent: maximal activity occurs when irinotecan is administered prior to 5-FU. In this phase I study, irinotecan is administered in combination with UFT and leucovorin in patients with advanced solid tumors.