Articles by Mehmet Asim Bilen, MD

Episode 14: Multidisciplinary Care Insights Across World GU 2025
ByManojkumar Bupathi, MD, MS,Benjamin Garmezy, MD,Mehmet Asim Bilen, MD,Sid Sadler,Kerry R. Schaffer, MD,Mark T. Fleming, MD,Jeff Yorio, MD,Mike Lattanzi, MD,Elizabeth Kessler, MD,Benjamin L. Maughan, MD, PharmD,Alan Tan, MD Panelists and presenters attending World GU 2025 shared their perspectives on optimizing the management of prostate, kidney, and bladder cancers.

Clinical Pearls on Recent Advances and the Future of Treatment in RCC
ByDavid Aggen, MD, PhD,Robert S. Alter, MD,Arnab Basu, MD, MPH, FACP,Mehmet Asim Bilen, MD,Chung-Han Lee, MD, PhD, Memorial Sloan Kettering Cancer Center Mehmet Asim Bilen, MD, summarizes recent advances in metastatic RCC and looks towards the future of the field.

Reflections on Novel Targets and Emerging Regimens for RCC
ByDavid Aggen, MD, PhD,Robert S. Alter, MD,Arnab Basu, MD, MPH, FACP,Mehmet Asim Bilen, MD,Chung-Han Lee, MD, PhD, Memorial Sloan Kettering Cancer Center Arnab Basu, MD, MPH, FACP, weighs in on novel therapeutic targets and emerging regimens that may further improve kidney cancer outcomes.

OncView™ Podcast: Safety and Efficacy of Available Treatment Options and Considerations for Patient Management in Metastatic RCC
ByDavid Aggen, MD, PhD,Robert S. Alter, MD,Arnab Basu, MD, MPH, FACP,Mehmet Asim Bilen, MD,Chung-Han Lee, MD, PhD, Memorial Sloan Kettering Cancer Center In an OncView™ program, David H. Aggen, MD, PhD, Robert S. Alter, MD, Arnab Basu, MD, MPH, FACP, Mehmet Asim Bilen, MD, and Chung-Han Lee, MD, MPH, offer their expert insights for the treatment of RCC.

The Importance of Team-Based Management and Patient Communication
ByDavid Aggen, MD, PhD,Robert S. Alter, MD,Arnab Basu, MD, MPH, FACP,Mehmet Asim Bilen, MD,Chung-Han Lee, MD, PhD, Memorial Sloan Kettering Cancer Center Robert Alter, MD, comments on the importance of team-based care and frequent, timely communication in managing patients with RCC.

Clinical Pearls on Tailoring Dosing Strategies in Metastatic Kidney Cancer
ByDavid Aggen, MD, PhD,Robert S. Alter, MD,Arnab Basu, MD, MPH, FACP,Mehmet Asim Bilen, MD,Chung-Han Lee, MD, PhD, Memorial Sloan Kettering Cancer Center David Aggen, MD, PhD, identifies dosing strategies that may maximize treatment efficacy while minimizing toxicity in patients with kidney cancer.

Considerations for Patient-Focused, Shared Decision-Making in RCC
ByDavid Aggen, MD, PhD,Arnab Basu, MD, MPH, FACP,Robert S. Alter, MD,Mehmet Asim Bilen, MD,Chung-Han Lee, MD, PhD, Memorial Sloan Kettering Cancer Center Chung-Han Lee, MD, PhD, delves into clinical and logistical factors that influence patient-focused, shared-decision making for those with metastatic RCC.

Patient-Specific Factors Impacting Treatment Choices in RCC
ByDavid Aggen, MD, PhD,Robert S. Alter, MD,Arnab Basu, MD, MPH, FACP,Mehmet Asim Bilen, MD,Chung-Han Lee, MD, PhD, Memorial Sloan Kettering Cancer Center Mehmet Asim Bilen, MD, reviews patient-specific factors such as comorbidities, RCC histology, and metastatic status that may factor into treatment decision-making.

Strategies for Prevention and Management of Adverse Events
ByDavid Aggen, MD, PhD,Robert S. Alter, MD,Arnab Basu, MD, MPH, FACP,Mehmet Asim Bilen, MD,Chung-Han Lee, MD, PhD, Memorial Sloan Kettering Cancer Center Chung-Han Lee, MD, PhD, provides a commentary on strategies for preventing and managing treatment-related adverse events in metastatic RCC.

Balancing Treatment Efficacy with Toxicity in Metastatic RCC
ByDavid Aggen, MD, PhD,Robert S. Alter, MD,Arnab Basu, MD, MPH, FACP,Mehmet Asim Bilen, MD,Chung-Han Lee, MD, PhD, Memorial Sloan Kettering Cancer Center David Aggen, MD, PhD, describes the challenges of balancing treatment efficacy versus toxicity and tolerability in patients with kidney cancer.

Common Adverse Events with Single-Agent or Combination Therapy
ByDavid Aggen, MD, PhD,Robert S. Alter, MD,Arnab Basu, MD, MPH, FACP,Chung-Han Lee, MD, PhD, Memorial Sloan Kettering Cancer Center,Mehmet Asim Bilen, MD Mehmet Asim Bilen, MD, provides an overview of commonly observed adverse events in patients with metastatic RCC receiving single-agent or combination therapy.

Conclusions: Lenvatinib + Pembrolizumab or Everolimus for Advanced Renal Cell Carcinoma
ByBrian I. Rini, MD,Mehmet Asim Bilen, MD,Marie Carlo, MD,Robert J. Motzer, MD,Moshe Ornstein, MD, MA,Rana R. McKay, MD,Tom Powles, MBBS, MRCP, MD Brian Rini, MD, summarizes the thoughts of his colleagues on the use of lenvatinib plus pembrolizumab to treat advanced renal cell carcinoma.

The Exciting Future of Advanced Renal Cell Carcinoma Management
ByMarie Carlo, MD,Mehmet Asim Bilen, MD,Robert J. Motzer, MD,Moshe Ornstein, MD, MA,Brian I. Rini, MD,Rana R. McKay, MD,Tom Powles, MBBS, MRCP, MD A panel of oncologists look at what’s in the pipeline for advanced renal cell carcinoma, including trials and treatment options.

Unmet Needs in Advanced Renal Cell Carcinoma Management
ByMehmet Asim Bilen, MD,Marie Carlo, MD,Robert J. Motzer, MD,Moshe Ornstein, MD, MA,Brian I. Rini, MD,Rana R. McKay, MD,Tom Powles, MBBS, MRCP, MD Two kidney cancer experts explore the current unmet needs for patients with advanced renal cell carcinoma.

Renal Cell Carcinoma: Future Directions in Care
ByRobert J. Motzer, MD,David Aggen, MD, PhD,Robert S. Alter, MD,Mehmet Asim Bilen, MD,Brian I. Rini, MD Closing out their discussion on renal cell carcinoma management, experts highlight unmet needs and look toward the future treatment landscape.

Treatment Strategies for Patients Who Progress on Adjuvant Pembrolizumab
ByRobert J. Motzer, MD,David Aggen, MD, PhD,Robert S. Alter, MD,Mehmet Asim Bilen, MD,Brian I. Rini, MD Following the advent of adjuvant pembrolizumab in high-risk renal cell carcinoma, experts consider treatment strategies for patients who progress on adjuvant pembrolizumab.

Is Adjuvant Pembrolizumab Standard of Care in Patients at Risk of Recurrence?
ByRobert J. Motzer, MD,David Aggen, MD, PhD,Robert S. Alter, MD,Mehmet Asim Bilen, MD,Brian I. Rini, MD Considerations for whether adjuvant pembrolizumab is the new standard of care for patients with renal cell carcinoma at intermediate or high risk of recurrence.

Patient Profile 3: RCC Treated With Adjuvant Pembrolizumab Postnephrectomy
ByRobert J. Motzer, MD,David Aggen, MD, PhD,Robert S. Alter, MD,Mehmet Asim Bilen, MD,Brian I. Rini, MD Expert panelists review a clinical scenario of renal cell carcinoma managed with adjuvant pembrolizumab postnephrectomy based on results of the KEYNOTE-564 trial.

Unmet Needs in the Front-Line Setting for Renal Cell Carcinoma
ByMehmet Asim Bilen, MD,Marie Carlo, MD,Robert J. Motzer, MD,Moshe Ornstein, MD, MA,Brian I. Rini, MD,Rana R. McKay, MD,Tom Powles, MBBS, MRCP, MD A look at the current unmet needs in front-line renal cell carcinoma treatment.

Patient Quality of Life on Lenvatinib plus Pembrolizumab Treatment for Renal Cell Carcinoma
ByMehmet Asim Bilen, MD,Marie Carlo, MD,Robert J. Motzer, MD,Moshe Ornstein, MD, MA,Brian I. Rini, MD,Rana R. McKay, MD,Tom Powles, MBBS, MRCP, MD Oncologists review quality of life data for patients with renal cell carcinoma receiving lenvatinib plus pembrolizumab combination treatments.

Safety and Efficacy Data: The JAVELIN Renal 101 Trial
ByDavid Aggen, MD, PhD,Robert S. Alter, MD,Arnab Basu, MD, MPH, FACP,Mehmet Asim Bilen, MD,Chung-Han Lee, MD, PhD, Memorial Sloan Kettering Cancer Center Chung-Han Lee, MD, PhD, discusses data from the JAVELIN Renal 101 trial of axitinib/avelumab versus sunitinib in metastatic RCC.

Safety and Efficacy Data: The CheckMate 214 Trial
ByDavid Aggen, MD, PhD,Robert S. Alter, MD,Arnab Basu, MD, MPH, FACP,Mehmet Asim Bilen, MD,Chung-Han Lee, MD, PhD, Memorial Sloan Kettering Cancer Center Mehmet Asim Bilen, MD, summarizes data from the CheckMate 214 trial on the safety and efficacy of ipilimumab/nivolumab versus sunitinib.

Dosing Lenvatinib for Treatment of Advanced Renal Cell Carcinoma
ByMehmet Asim Bilen, MD,Marie Carlo, MD,Robert J. Motzer, MD,Moshe Ornstein, MD, MA,Brian I. Rini, MD,Rana R. McKay, MD,Thomas Powles, MBBS, MCRP, MD Kidney cancer experts explain how they dose lenvatinib in advanced renal cell carcinoma treatment to mitigate toxicities.

Dosing Lenvatinib for First-Line Renal Cell Carcinoma Treatment
ByMehmet Asim Bilen, MD,Marie Carlo, MD,Robert J. Motzer, MD,Moshe Ornstein, MD, MA,Brian I. Rini, MD,Rana R. McKay, MD,Thomas Powles, MBBS, MD, MRCP An explanation of dosing strategies when treating patients with renal cell carcinoma in the first-line with lenvatinib.

Treating Favorable Risk Patients with Renal Cell Carcinoma with Lenvatinib
ByMehmet Asim Bilen, MD,Marie Carlo, MD,Robert J. Motzer, MD,Moshe Ornstein, MD, MA,Brian I. Rini, MD,Rana R. McKay, MD,Tom Powles, MBBS, MRCP, MD Experts discuss the safety of treating renal cell carcinoma with lenvatinib within different patient risk populations.

Risk Factors in the Management of Advanced Renal Cell Carcinoma
ByMehmet Asim Bilen, MD,Marie Carlo, MD,Robert J. Motzer, MD,Moshe Ornstein, MD, MA,Brian I. Rini, MD,Rana R. McKay, MD,Tom Powles, MBBS, MRCP, MD Possible comorbidities and other risk factors in advanced renal cell carcinoma that would affect potential treatment regimens.

Novel Combination Strategies in the Treatment of Renal Cell Carcinoma
ByRobert J. Motzer, MD,David Aggen, MD, PhD,Robert S. Alter, MD,Mehmet Asim Bilen, MD,Brian I. Rini, MD Before closing out their discussion on intermediate-risk RCC, experts review frontline triplet combinations and possible treatment options following relapse after nivolumab-ipilimumab.

Optimizing RCC Management: Addressing Quality-of-Life Measures and Metastasis
ByRobert J. Motzer, MD,David Aggen, MD, PhD,Robert S. Alter, MD,Mehmet Asim Bilen, MD,Brian I. Rini, MD Comprehensive discussion on how to best treat patients with renal cell carcinoma and brain or bone metastasis.

Discontinuing IO/IO Therapy in Intermediate-Risk Renal Cell Carcinoma
ByRobert J. Motzer, MD,David Aggen, MD, PhD,Robert S. Alter, MD,Mehmet Asim Bilen, MD,Brian I. Rini, MD Shared insight on the adverse event profile of immunotherapy combination regimens in renal cell carcinoma, including advice on when it is appropriate to discontinue therapy.

Patient Profile 2: Intermediate-Risk RCC Treated With Ipilimumab + Nivolumab
ByRobert J. Motzer, MD,David Aggen, MD, PhD,Robert S. Alter, MD,Mehmet Asim Bilen, MD,Brian I. Rini, MD Expert perspectives on the clinical scenario of a patient with intermediate-risk renal cell carcinoma, who is managed with the immunotherapy combination of ipilimumab and nivolumab.