
Combining zedoresertib with lunresertib yielded activity in patients with CCNE1-altered platinum-resistant ovarian cancer in the phase 1 MYTHIC trial.

Combining zedoresertib with lunresertib yielded activity in patients with CCNE1-altered platinum-resistant ovarian cancer in the phase 1 MYTHIC trial.


According to Timothy A. Yap, MBBS, PhD, FRCP, there is an unmet need in oncology for treating patients with CCNE1, FBXW7, and PPP2R1A genomic alterations.

Timothy A. Yap, MBBS, PhD, FRCP, presented data from the MYTHIC trial, demonstrating a 60% ORR at the RP2D in patients with CCNE1-amplified PROC.