Risks and Benefits of Tamoxifen TherapyByVasilios J. Assikis, MD,V. Craig Jordan, OBE, PhD, DScFebruary 1st 1997Tamoxifen is the most widely prescribed endocrine therapy for breast cancer, with more than 7.5 million woman-years of clinical experience. Tamoxifen has both antiestrogenic and estrogenic activity. The antiestrogenic activity