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For many individuals, keloids present a symptomatic and cosmetic issue after tissue injury. Surgical excision followed by immediate adjuvant RT provides excellent local control and cosmesis with minimal toxicity. Treatment with both prescribed regimens yielded equal results.
A hypofractionated course of 8 Gy/1 fx radiation therapy in the treatment of bony multiple myeloma metastases is an efficient and effective way to reduce pain and reduce the time from the completion of radiation therapy to the start of chemotherapy in patients with multiple myeloma.
Systemic inflammatory markers are independent prognostic factors for survival in oropharyngeal cancer patients treated with radiation therapy. Future investigations to validate the identified cut points and to develop risk-adaptive treatment strategies are needed.
Assuming IMRT became more prevalent from 2000 to 2002, the annual incidence rate of second malignancy remains consistently below that of patients who receive no radiation. This pattern contradicts the argument that IMRT significantly increases the risk for second malignancy.
Differences in the legal needs of economically and geographically diverse patients with cancer suggest that those needs are not determined solely by disease state but that they also correspond with geographic and economic characteristics.
Forming a successful quality improvement project is challenging at times but ultimately provides an excellent educational experience for residents and a rewarding opportunity to help patients.
From our institutional experience, low-dose RT in addition to docetaxel and cetuximab is well tolerated. More durable treatment options may exist for definitive treatment; however, this protocol may offer low-morbidity palliation in select patients.
Increasing time from diagnosis to simulation and from simulation until the start of therapy is associated with worse outcomes. Patients with HPV-associated oropharyngeal squamous cell carcinoma are at increased risk of nodal progression before treatment.
Rates of clinically significant GI and GU toxicities are modest following SBRT plus IMRT. Placement of rectal spacers may decrease rectal toxicity. Future studies should also identify dosimetric predictors of these toxicities.
We conclude that every patient has the right to have continent diversion. An orthotopic bladder approach should be considered first, and if it is not feasible, then the Indiana pouch could be a suitable alternative with no additional complications, unless this procedure is contraindicated.
L5HU and psoas L4–L5, surrogates for bone mineral density and muscle mass, respectively, were independent predictors of overall survival in a multivariable model controlling for age, comorbidity, prostate cancer risk grouping, race, and ADT.
Intraductal papillary mucinous neoplasms with high malignant potential appear to have distinct imaging properties. Further validation of these findings may address a major clinical need in this population by identifying those most likely to benefit from surgical resection.
In the present investigation, we observed a significant and independent radiographic control benefit with the addition of first-line TKIs to stereotactic radiosurgery.
Radiation therapy is associated with improved survival in surgically resected pT4 or N+ patients with ampullary adenocarcinoma.
SBRT appears to have a survival benefit in patients with locally advanced pancreatic cancer, especially after the delivery of maximal multiagent chemotherapy. SBRT may play a role in tumor downstaging and allow patients with locally advanced pancreatic cancer to undergo surgery.
In this national hospital-based study, the addition of postoperative radiation therapy with or without chemotherapy following esophagectomy was associated with improved survival for patients with node-positive disease or positive margins.
Esophageal melanoma is an aggressive disease with very poor outcomes. Esophagectomy may result in reasonable survival for localized disease. Treatment with RT did not result in any surviving patients at 3 years.
Significant variability in clinical target volume localization of gastric marginal zone lymphoma occurs if daily RT is delivered based on alignment to bony anatomy. MRI-guided RT allows for significant reduction in planning target volumes expansions without compromising coverage.
In this first-of-its-kind analysis, assessing the radiosensitivity of multiple metastases from the same patient, we note a similar radiosensitivity fingerprint for lesions from the liver and lung from the same primary lesion.
In this large population dataset, adjuvant radiation was associated with an improvement in OS in a modern cohort of patients. Patients with distal tumors, higher-grade disease, negative lymph nodes, and larger tumors may derive a greater benefit with radiation.
Central nervous system PRT appears to be well tolerated. Radiographic findings suggest that periventricular white matter may be more sensitive to radiation injury. Strategies to further reduce dose are warranted, as is the development of imaging and molecular biomarkers to identify patients at higher risk.
The data suggest that different cellular pathways may be activated, depending on RT regimen, leading to differential biological effects. A better understanding of these mechanisms might assist in building novel combination-treatment regimens.
We document survival and prognostic factors of SBRT for breast cancer oligometastases in a single institution. Information about the survival benefit of SBRT following chemotherapy awaits the results of the phase II/III NRG BR002 trial.
Protons for postmastectomy radiation therapy, particularly in cases of challenging anatomy, result in decreased dose to normal structures compared with photon plans, with acceptable acute toxicity. Dose escalation after double-scattered proton should be used with caution to avoid skin toxicity.
Our study suggests that breast-conserving therapy for early-stage male breast cancer yields comparable cause-specific survival rates when compared with mastectomy.
With aggressive trimodality therapy, excellent locoregional control was achieved in patients with newly diagnosed inflammatory breast cancer. However, DFS and OS are suboptimal, despite modern trimodality treatment.
Single-fraction RT to the femur was effective in the prevention of femoral fractures. The pain score was also decreased in our patient population. Further studies are needed to explore 8 Gy/1 fx against standard radiation as a more effective means of delivering therapeutic and convenient treatment in metastatic patients.
Although the female RO full professors in our cohort were similar overall in terms of productivity and NIH funding to their male colleagues, they tended to have longer times to promotion earlier in their careers at lower academic ranks. Women may experience barriers to productivity early in their careers that may delay promotion.
Less than 50% of the level I LN volume was covered by 90% PD; less than 30% was covered by 95% PD. Mean (29 Gy) and median (30 Gy) doses to the level I LN were subtherapeutic. There was a moderate correlation between V20 ipsilateral lung and coverage of level I LNs.
The Standard Chemical Company was organized in 1911 to produce and sell radium. It was the first American company to do so. Most of the radium went to Europe, as there was little demand in America.
