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Nearly a decade ago, irinotecan (CPT-11 [Camptosar]) began clinical development in Japan. Early clinical trials in that country recognized its anti-tumor activity in a variety of advanced malignancies, including stomach, colon, cervical, and lung

Radiosurgery uses stereotactic targeting methods to precisely deliver highly focused, large doses of radiation to small intracranial tumors and arteriovenous malformations (AVMs). This article reviews the most common

Phase I trials of irinotecan (CPT-11 [Camptosar]), conducted at Johns Hopkins and the University of Texas, San Antonio, demonstrated some activity in patients with refractory advanced cancer. Three pivotal phase II studies of

Advanced gastric carcinoma remains an incurable disease with a median survival of 6 to 9 months, and available therapeutic approaches are predominantly palliative. In small controlled trials, systemic chemotherapy has

Tremendous progress has been made in the medical treatment of advanced colorectal cancer during the past 2 to 3 years, due to the availability of several new drugs. Of these new agents, irinotecan (CPT-11 [Camptosar]) seems

Most clinical drug regimens for irinotecan (CPT-11 [Camptosar]) have been empirically based on classic in vivo pharmacokinetic and pharmacodynamic considerations. We propose an alternative approach that attempts to

Most of the clinical experience with irinotecan (CPT-11 [Camptosar]) has been with either a weekly or an every-3-week schedule. Recent phase I trials have explored new routes and schedules of administration. One approach

The objective response rate is the initial method to assess the activity of a novel anticancer agent. Response rates may not characterize a new agent’s clinical benefit, however, especially if moderate to severe toxicity may be

It has been hypothesized that intratumoral thymidylate synthase (TS) gene expression might be used to select therapy for patients with disseminated colorectal cancer. We recently

Based on high tumoricidal activity of the camptothecin analogs topotecan (Hycamtin), irinotecan (CPT-11[Camptosar]), and 9-aminocamptothecin (9-AC) in preclinical studies, clinical trials began testing these agents

Irinotecan (CPT-11 [Camptosar]) is an important new chemotherapeutic drug that demonstrates activity against a broad spectrum of malignancies, including carcinomas of the colon, stomach, and lung. Unfortunately, frequent and

The unique mechanism of action of irinotecan (CPT-11 [Camptosar]), topoisomerase I inhibition, together with the results of preclinical studies, suggest that the drug’s antitumor and toxicologic effects may be schedule-dependent.

Clinical results with irinotecan (CPT-11 [Camptosar]) and other camptothecin derivatives in various cancers, although encouraging, have fallen short of the expectations predicted by preclinical models. One proposed

LOS ANGELES--If the basic protocol for imparting bad news to cancer patients could be reduced to a T-shirt slogan, it would be, "Before you tell, ask," Robert Buckman, MD, PhD, said at an educational session on breaking bad news to cancer patients at the American Society of Clinical Oncology (ASCO) meeting. "Find out the patient’s expectations before you give information," he said.

WASHINGTON--Up to one-third of callers to the National Cancer Institute’s hot line for cancer information(1-800-4-CANCER) get a busy signal or hang up because of the long wait for someone to pick up, according to a report by the inspector general of the Department of Health and Human Services.

LOS ANGELES--Visitors to the Exhibitor’s Hall at this year’s ASCO meeting had the opportunity to walk in the shoes of a patient with cancer-related fatigue at Ortho-Biotech’s In My Steps virtual reality experience, developed in cooperation with cancer patients and the Fatigue Coalition.

In his article, "Genetic Testing for Cancer Susceptibility: Challenges for Creators of Practice Guide-lines" [11(11A):171-176, 1997], Henry Greely, JD, provides a comprehensive review of the complex issues that patients consider when deciding

BETHESDA, Md--NIH director Harold Varmus, MD, has named Neal Nathanson, MD, to serve as the new director of NIH’s Office of AIDS Research (OAR). Dr. Nathanson, a leader in viral pathogenesis, comes to the NIH from the University of Pennsylvania Medical Center, where he was Vice Dean for Research and Research Training. He is an active member of the NIH AIDS Vaccine Research Committee, chaired by Dr. David Baltimore.

LOS ANGELES--An exhibit featuring works by five women artists who have lived with cancer was displayed in conjunction with the 1998 Oncology Nursing Society and ASCO meetings.

At its 15th Annual Human Services Award Dinner in New York, Cancer Care, Inc, honored Cokie Roberts with its Regulus Award for members of the media, Carol Webb of Ortho Biotech with its Human Services Award, and H. Frank Doroff of

SAN DIEGO--Since thrombopoie-tin (TPO), the ligand for the Mpl receptor, was cloned by four separate laboratories in 1994, researchers have been exploring, with animal models and in clinical settings, how it can be used to benefit patients. Kenneth Kaushansky, MD, a prominent researcher in the field, summarized some of the results of the studies to date, at the Sixth International Symposium on Recent Advances in Hematopoietic Stem Cell Transplantation, sponsored by the University of California, San Diego.

WASHINGTON--One in four Americans starting treatment for HIV infection does not receive care that meets the most up-to-date and recognized standards, according to the results of the first National HIV/AIDS Treatment Survey.

NEW ORLEANS--A mutation in the gene for E-cadherin may partly explain the high rate of stomach cancer among the Maori, the indigenous people of New Zealand, Parry Guilford, PhD, a research fellow in the Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand, reported at the 89th annual meeting of the American Association for Cancer Research.

The Jefferson Cancer Network of Thomas Jefferson University’s Kimmel Cancer Center recently established a cooperative program known as the Jefferson Oncology Group among its members. The purpose of this new cooperative program is to

Scientists at Ohio University Edison Biotechnology Institute have used a nonviral gene expression system, invented and patented by Ohio University several years ago, to eliminate human cancer cells in animals. The investigators reported achieving

HOUSTON--About 50% of patients function well when dealing with the diagnosis of cancer, but the other 50% need assistance adapting to the trauma brought on by the disease and its treatment, Debra Sivesind, RN, said at M.D. Anderson Cancer Center’s 2nd Annual Nursing Conference.

BETHESDA, Md--In an effort to increase participation in clinical trials, the National Cancer Institute is developing a marketing campaign aimed at selling patients on the importance of taking part in experimental treatments. "This effort represents a new and an important activity by NCI," director Richard D. Klausner told the National Cancer Advisory Board (NCAB). "The marketing initiative is aimed at developing approaches to getting the word out about the value and the opportunities of clinical trials," he said.

WASHINGTON--A leading House Democrat has urged his colleagues to approve the funds necessary to make a proposed National Environmental Childhood Cancer Registry a reality.

BETHESDA, Md--National Cancer Institute officials have committed themselves to providing information to women and their physicians to help women make an informed decision whether to take tamoxifen (Nolvadex) to prevent breast cancer. But some members of the NCI’s own advisory board have questioned whether the information provided to date is too complex for most women to grasp.

NEW YORK--American and European epidemiologic surveys indicate that as many as 90% of patients with end-stage cancer have pain severe enough to warrant treatment with opioid drugs. Other surveys indicate that this pain is widely undertreated. A survey of roughly 1,100 oncologists in the Eastern Cooperative Oncology Group (ECOG) showed that poor assessment of pain is perhaps the most common cause of inadequate treatment.