All News

SAN ANTONIO, Texas-Irinotecan is metabolized via CYP3A4 to the less active oxidative metabolites APC and NPC and is bioactivated in the liver and intestine by human carboxylesterases (hCE) to the topoisomerase I inhibitor SN-38 (Figure 1). The pharmacology of irinotecan (Camptosar, CPT-11), a water-soluble, semisynthetic derivative of camptothecin, was reviewed at the Vanderbilt University Symposium by John G. Kuhn, PharmD, of the Departments of Medicine and Pharmacology, University of Texas Health Science Center, San Antonio, and College of Pharmacy, University of Texas.

BUFFALO-New work on the role of schedule and dose in determining the efficacy of two classes of drugs-thymidylate synthase inhibitors and topoisomerase I inhibitors-was described by Youcef M. Rustum, PhD, at the Vanderbilt University Symposium. Dr. Rustum is senior vice president for scientific affairs and graduate education at Roswell Park Cancer Institute in Buffalo.

NEW ORLEANS-A genetic variant has been found to double an HIV-infected individuals’ risk of developing non-Hodgkin’s lymphoma (NHL). Charles S. Rabkin, MD, HIV/Cancer Coordinator, Viral Epidemiology Branch, National Cancer Institute, presented the report at the 92nd Annual Meeting of the American Association for Cancer Research (AACR).

FORT LAUDERDALE, Fla-Studies show that chronic lymphocytic leukemia (CLL) responds to therapy with alemtuzumab (Campath). However, the monoclonal antibody is immunosuppressive, and patients who receive it should be on prophylactic antibiotics, Susan O’Brien, MD, said at the 6th Annual Conference of the National Comprehensive Cancer Network (NCCN).

BETHESDA, Maryland-An understanding of how camptothecins intrude between topoisomerase I and DNA is helping to refine the anticancer activity of these drugs, and studies of the pathway from initial camptothecin binding to final cell death may help unravel the mechanisms behind drug resistance. Yves Pommier, MD, PhD, chief of the National Cancer Institute’s Laboratory of Molecular Pharmacology reviewed recent developments in these areas at the Vanderbilt University Symposium.

WASHINGTON-Tobacco companies are not getting the same bang for their advertising dollars as they once did. Cigarette sales in the United States in 1999, the first year affected by the Master Settlement Agreement between the tobacco industry and 46 states, dropped despite an increase in spending for advertising and promotions.

MEMPHIS-‘‘Camptothecin activity is schedule dependent and is very S-phase-specific at concentrations we can achieve in vivo," Peter J. Houghton, PhD, said while summarizing the results of preclinical studies with camptohecins. "Protracted administration is optimal, and threshold concentrations are critical," he continued. Dr. Houghton is chairman of the Department of Molecular Pharmacology at St. Jude Children’s Research Hospital in Memphis.

NEW YORK-The cisplatin/irinotecan combination produces responses among patients with gastric and esophageal cancers, David H. Ilson, MD, PhD, reported at the Vanderbilt University Symposium. Dr. Ilson is assistant attending physician in the Department of Gastrointestinal Oncology, Memorial Sloan-Kettering Cancer Center, New York.

LOS ANGELES-Researchers at Cedars-Sinai Medical Center’s Maxine Dunitz Neurosurgical Institute are conducting a clinical trial of temozolomide (Temodar) in patients with mixed gliomas or oligodendroglial tumors. They expect to enroll about 60 patients over a 30-month period.

WASHINGTON-Several House and Senate members have introduced bipartisan bills that would authorize the Food and Drug Administration (FDA) to regulate tobacco products. The measures are in response to a Supreme Court decision that rejected the FDA’s claim to such authority and held that "Congress has clearly precluded the FDA from asserting jurisdiction to regulate tobacco products."

NEW ORLEANS-A protein-based compound called BL22 produced complete remissions in patients with hairy cell leukemia resistant to standard therapy with purine analogs. Results of the phase I trial were reported at the 92nd Annual Meeting of the American Association for Cancer Research (AACR).

WASHINGTON-President Bush has asked Congress to appropriate a budget of $23.112 billion for the National Institutes of Health in fiscal year 2002, which begins Oct. 1. His request represents a $2.751 billion (13.5%) increase over the current fiscal year. The President also requested a budget of $4.177 billion for the National Cancer Institute, an increase of $439 million (11.7%).

NEW YORK-The need to test new biologically targeted therapies and the presence of vocal patient advocate groups are among the factors galvanizing the National Institutes of Health to seek wider patient participation in clinical trials, Mary McCabe, RN, said during a Cancer Care, Inc. teleconference. She also made clear that patients need to ask many questions before enrolling. Only 1% to 3% of cancer patients take part in clinical trials, said Ms. McCabe, director of the National Cancer Institute’s Office of Education and Special Initiatives. "We would like to see that change," she said.

LITTLE ROCK, Arkansas-Thalidomide appears to enhance the response rate produced by irinotecan (Camptosar) in metastatic colorectal cancer, while decreasing the drug’s gastrointestinal toxicities, reported Rangaswamy Govindarajan, MD. In addition, thalidomide is well tolerated at 400 mg/d, inhibits tumor necrosis factor-alpha, has antiangiogenic properties, and costimulates CD8+ T-cells, Dr. Govindarajan noted. He is assistant professor of medicine in the Division of Hematology/Oncology at the University of Arkansas for Medical Sciences, Little Rock, Arkansas.

NASHVILLE, Tennessee-"Camptothecins have radiosensitizing as well as cytotoxic effects, and combining a camptothecin such as irinotecan with radiation on the right schedule might produce a powerful antitumor regimen," according to Allan Chen, MD, PhD. Dr. Chen is assistant professor of radiation oncology at Vanderbilt University Medical Center in Nashville, Tennessee.

DURHAM, North Carolina- Topoisomerase I inhibitors have shown promising activity in difficult-to-treat tumors of the central nervous system (CNS), according to Henry S. Friedman, MD. In studies of camptothecins, both irinotecan (Camptosar) and topotecan (Hycamtin) showed "prodigious activity" in slowing tumor growth and causing tumor regression in subcutaneous xenografts of human gliomas, Dr. Friedman told those attending the Vanderbilt University Symposium. Dr. Friedman is Jones B. Powell, Jr., Professor of Neuro-Oncology at Duke University Medical Center in Durham, North Carolina.

PEAPACK, New Jersey-Potential directions for irinotecan (Camptosar) clinical research in the future and for the application of novel therapeutics were presented by Langdon Miller, MD, of Pharmacia Oncology Development in Peapack, New Jersey.

The article by Drs. Levine, Seneviratne, and Tulpule is an excellent review of the available literature on the incidence and treatment of lymphoma related to the acquired immunodeficiency syndrome (AIDS).

Advances in antiretroviral therapy have dramatically improved human immunodeficiency virus (HIV)-associated morbidity and mortality. The use of highly active antiretroviral therapy (HAART) has led to a decrease in the incidence of opportunistic diseases, including some malignancies. Moreover, increased use of effective antiretroviral therapy may alter the incidence, presentation, prognosis, and therapeutic recommendations for patients with acquired immunodeficiency syndrome (AIDS)-related non-Hodgkin’s lymphoma.

Over the past 3 decades, hematopoietic stem cell transplantation has become a lifesaving art that is applied to a variety of malignant and nonmalignant disorders.[1] In the 1970s, several groups demonstrated that advanced leukemia and aplastic anemia patients were cured using sibling-matched allogeneic bone marrow transplantation. By the 1980s, many published reports confirmed that relapsed and refractory lymphoma patients could attain long-term disease-free survival as a result of utilizing autologous bone marrow transplantation.

The demographics of the US population continue to change dramatically, as the absolute number and proportion of older people relative to the remainder of the population increases. Last year, the number of persons older than 65 years was estimated to be 35 million, representing almost 13% of the overall population; by 2030, the older population is expected to double. Along with the general aging of the population, the percentage of persons older than 85 years is also growing rapidly, as is the ethnic and racial diversity within the older population.

Over time, the spectrum of the acquired immune deficiency syndrome (AIDS) epidemic has changed, especially with the advent of highly active antiretroviral therapy (HAART). The goal of this article is to delineate changes

Estramustine is nornitrogen mustard linked to estradiol. It binds to tubulin and to microtubule-associated proteins, depolymerizes cytoplasmic microtubules, and disrupts the nuclear matrix. It has limited clinical

The aging of the population is a social phenomenon that will present a challenge to clinical practice in the 21st century. Women constitute a majority of the elderly population as they outlive males by 5 to 7 years. Ovarian,

This is the first in a series of reports on presentations from "Ensuring Quality Cancer Care," a symposium held in Chicago and sponsored by the Robert H. Lurie Comprehensive Cancer Center of Northwestern University and the VA Chicago Health Care System. The reports, which put the discussions into a broader context, have been prepared for ONI by researchers at Northwestern University, working under the direction of Dr. Charles L. Bennett.

An underinvestigated area of breast cancer survivorship involves the possible impairment of cognitive function following adjuvant chemohormonal therapy. Numerous reports of disturbing and disruptive changes in short- and

The editors of this impressive new book indicate in their preface that this text was compiled to give "undivided attention" to granulomatous disorders other than sarcoidosis. Toward that end, they have assembled an impressive array of experts from

WASHINGTON-The nation’s health care industry is broken and urgently needs reorganization and reform to fix it, a new Institute of Medicine (IOM) report asserts. As a beginning, the report proposes that Congress appropriate $1 billion over the next 3 to 5 years to begin repairing what it calls a disjointed and inefficient system.

SkyePharma PLC and Chiron Corporation have received clearance from the US Food and Drug Administration (FDA) to return cytarabine liposome injection (DepoCyt) to the market. Liposomal cytarabine is the only FDA-approved treatment for

WASHINGTON-Smoking prevalence varies considerably from state to state among both adults and students, according to new data from the Centers for Disease Control and Prevention (CDC). In 1999, adult prevalence ranged from 13.9% in