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Opinion|Videos|January 13, 2025

Do We Start Luspatercept at the Highest Dose and Titrate Down or Start Low and Titrate Up?

Panelists discuss how to optimize luspatercept dosing strategies by evaluating the benefits and risks of starting at maximum dose with downward titration vs initiating at lower doses with upward adjustments.

Episodes in this series

EP. 1 COMMANDS: Long-Term Analysis, Changes in RBC Transfusion Burden, Hemoglobin Levels and ELEMENTS Trial

EP. 1 COMMANDS: Long-Term Analysis, Changes in RBC Transfusion Burden, Hemoglobin Levels and ELEMENTS Trial

EP. 2 MEDALIST and IMerge Trial Presentation and Discussion

EP. 2 MEDALIST and IMerge Trial Presentation and Discussion

EP. 3 Debate: Do We Treat First With ESAs or With Luspatercept?

EP. 3 Debate: Do We Treat First With ESAs or With Luspatercept?

EP. 4 Do We Start Luspatercept at the Highest Dose and Titrate Down or Start Low and Titrate Up?

EP. 5 Clinical Scenario: Patient Receiving First-Line ESA Without a Marked Response: What Do You Do Next?

EP. 5 Clinical Scenario: Patient Receiving First-Line ESA Without a Marked Response: What Do You Do Next?

EP. 6 Clinical Scenario: How Do We Treat Patients With Ring Sideroblast/Genetic Abnormalities?

EP. 6 Clinical Scenario: How Do We Treat Patients With Ring Sideroblast/Genetic Abnormalities?

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