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Opinion|Videos|November 20, 2024

Dosing Interval and Considerations for Bispecifics Combination in Relapsed Refractory Multiple Myeloma

Author(s)Ajai Chari, MD, Thomas G. Martin, MD, Jens Hillengass, MD, PhD

Panelists discuss how optimizing dosing intervals and carefully considering combination strategies for bispecific antibodies in relapsed/refractory multiple myeloma could enhance treatment efficacy while managing toxicities and improving patient quality of life.

Episodes in this series

9 Experts are featured in this series.

EP. 1 Talquetamab, a GPRC5DxCD3 bispecific antibody (BsAb), for Relapsed Refractory Multiple Myeloma: MonumenTAL-1 Data and Implications

9 Experts are featured in this series.

EP. 2 Bispecific Antibody Combinations In Relapsed Refractory Multiple Myeloma: TRIMM-2 Study

9 Experts are featured in this series.

EP. 3 Bispecific Antibody Combinations In Relapsed Refractory Multiple Myeloma: RedirecTT-1 Follow-Up

9 Experts are featured in this series.

EP. 4 Prophylactic Tocilizumab in MajesTEC-1 for the Reduction of CRS

9 Experts are featured in this series.

EP. 5 OPTec: Outpatient Step Up Administration of Teclistamab: Implications in Real-World Practice

9 Experts are featured in this series.

EP. 6 Sequencing Therapies in Relapsed Refractory Multiple Myeloma: Bispecifics and CAR T-Cell Therapies

9 Experts are featured in this series.

EP. 7 Dosing Interval and Considerations for Bispecifics Combination in Relapsed Refractory Multiple Myeloma

9 Experts are featured in this series.

EP. 8 Clinical Scenario: A 58-Year Old Woman with Relapsed Refractory Mutiple Myeloma, post-ASCT, MRD-negative, on Bispecific Therapy

9 Experts are featured in this series.

EP. 9 Clinical Scenario: Implementation of Bispecific Therapy for Relapsed Refractory Multiple Myeloma in a Community Center

EP. 10 Experts Discuss Choosing Bispecifics and Sequencing Options in Multiple Myeloma

EP. 10 Experts Discuss Choosing Bispecifics and Sequencing Options in Multiple Myeloma

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Stay up to date on recent advances in the multidisciplinary approach to cancer.

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ByJames R. Berenson, MD, FACP

December 12th 2025

$The 6- and 12-month PFS rates were 76.4% and 68.2%, respectively, in patients with relapsed/refractory multiple myeloma who discontinued treatment with teclistamab early.$

Discontinuing Teclistamab Early Yields Comparable Efficacy vs Continuous Therapy in RRMM

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Current FDA expectations may allow patients to return to their community physicians at 2 weeks after administration of anitocabtagene autoleucel.

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ByKrina K. Patel, MD, MSc

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Most CRS events were low grade with elranatamab plus daratumumab and lenalidomide without prophylactic tocilizumab in patients with multiple myeloma.

Tumor Burden Does Not Impact CRS Risk With Elranatamab Combo in Myeloma

ByRoman Fabbricatore

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Data from the phase 1b MonumenTAL-2 study support continued investigation of talquetamab/pomalidomide in the phase 3 MonumenTAL-6 trial.

Talquetamab/Pomalidomide Shows Deep Responses in R/R Multiple Myeloma

December 10th 2025

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A New Era of Targeted Therapy for Advanced NSCLC: Exploring Future Directions for Bispecific Antibodies and ADCs

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Advances in Managing EGFR-Mutant NSCLC: Applying Evidence Across the Disease Continuum

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(CME Track) Antibody–Drug Conjugates in Oncology: The Essentials of AE Management for Better Patient Outcomes

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Personalized Approaches in NSCLC: Early Detection, Molecular Testing, and Targeted Therapies

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Community Practice Connections™: Optimizing SCLC Treatment Strategies and Managing Adverse Events Across Disease Stages

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Community Practice Connections™: DLL3-Targeting Bispecific Antibodies for Small Cell Lung Cancer—From Innovation to Practice

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Jacob Sands, MD; Anne Chiang, MD, PhD

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