Exposure to pesticides raises myeloma risk
People who apply certain pesticides double their chance of developing multiple myeloma, compared with individuals in the general population.
People who apply certain pesticides double their chance of developing multiple myeloma, compared with individuals in the general population. Data culled from a U.S. Agricultural Health Study found higher rates of monoclonal gammopathy of undetermined significance in 678 individuals who applied certain pesticides, compared with a control population. MGUS is a precancerous condition that can lead to multiple myeloma (Blood 113:6386-6391, 2009).
The participants (median age 60) were farmers in Iowa and North Carolina who were licensed to apply restricted-use pesticides. The researchers found a significantly increased risk of MGUS among users of dieldrin (5.6-fold increase in risk), carbon-tetrachloride/carbon disulfide (3.9-fold increase in risk), and chlorothalonil (2.4-fold increase in risk).
FDA Approves Cilta-Cel for Relapsed/Refractory Myeloma After 1 Therapy
April 6th 2024The FDA has approved ciltacabtagene autoleucel for the treatment of adult patients with relapsed/refractory multiple myeloma who have received at least 1 prior line of treatment, including a proteasome inhibitor and an immunomodulatory agent, and are refractory to lenalidomide.
Relapsed/Refractory Multiple Myeloma Trial Updates From ASCO 2023
August 7th 2023Experts from Mayo Clinic and The University of Texas MD Anderson Cancer Center discuss results from multiple myeloma trials presented at the 2023 American Society of Clinical Oncology Annual Meeting and how they may apply to clinical practice.
