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Opinion|Videos|February 14, 2024

Navigating Treatment Resistance and Sequencing in CLL

Author(s)Sameer A. Parikh, MD, Sikander Ailawadhi, MD, Mazie Tsang, MD, MAS, MS

Sameer A Parikh, MD, leads an expert discussion regarding emerging resistance data and its potential impact on treatment sequencing.

Episodes in this series

EP. 1 Evolving Front-line Treatment Options for CLL

EP. 1 Evolving Front-line Treatment Options for CLL

EP. 2 Navigating 1L Treatment Selection with BTKis in CLL

EP. 2 Navigating 1L Treatment Selection with BTKis in CLL

EP. 3 Updates on BTKi Monotherapy for CLL in the Frontline Setting

EP. 3 Updates on BTKi Monotherapy for CLL in the Frontline Setting

EP. 4 The Role of BTKi + Obinutuzumab for 1L Treatment of CLL

EP. 4 The Role of BTKi + Obinutuzumab for 1L Treatment of CLL

EP. 5 Expert Perspectives on Fixed Duration Therapy with Venetoclax + Obinutuzumab

EP. 5 Expert Perspectives on Fixed Duration Therapy with Venetoclax + Obinutuzumab

EP. 6 Updates on Combination Treatment Approaches with BTKi + Venetoclax

EP. 6 Updates on Combination Treatment Approaches with BTKi + Venetoclax

$EP. 7 Navigating Treatment Selection for CLL in the Relapsed/Refractory Setting$

EP. 7 Navigating Treatment Selection for CLL in the Relapsed/Refractory Setting

EP. 8 Expert Insights on Extended Follow-Up Data from ALPINE and ELEVATE-RR

EP. 8 Expert Insights on Extended Follow-Up Data from ALPINE and ELEVATE-RR

EP. 9 Consideration Factors in Treatment Selection for BTKi Therapy in R/R CLL

EP. 9 Consideration Factors in Treatment Selection for BTKi Therapy in R/R CLL

EP. 10 Key Considerations in Managing Hypertension Risk with BTKis in CLL

EP. 10 Key Considerations in Managing Hypertension Risk with BTKis in CLL

EP. 11 Expert Perspectives on Managing Risk of Atrial Fibrillation with BTKis in CLL

EP. 11 Expert Perspectives on Managing Risk of Atrial Fibrillation with BTKis in CLL

EP. 12 Managing Bleeding Risk in Patients with CLL on BTKi Therapy

EP. 12 Managing Bleeding Risk in Patients with CLL on BTKi Therapy

EP. 13 Utilizing Real-World Data for Informed Decision-Making in CLL

EP. 13 Utilizing Real-World Data for Informed Decision-Making in CLL

EP. 14 Navigating Treatment Resistance and Sequencing in CLL

EP. 14 Navigating Treatment Resistance and Sequencing in CLL

EP. 15 Advancements with Novel Treatment Approaches in CLL

EP. 15 Advancements with Novel Treatment Approaches in CLL

EP. 16 Future Perspectives and Unmet Needs in CLL

EP. 16 Future Perspectives and Unmet Needs in CLL

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Stay up to date on recent advances in the multidisciplinary approach to cancer.

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John H. Strickler, MD; Stacey A. Cohen, MD; Aparna Parikh, MD; Kanwal P.S. Raghav, MBBS, MD

Medical Crossfire®: Improving Patient Outcomes in Myeloproliferative Neoplasms With Novel Therapeutic Approaches

Medical Crossfire®: Improving Patient Outcomes in Myeloproliferative Neoplasms With Novel Therapeutic Approaches

Rami Komrokji, MD; Gabriela Hobbs, MD; John Mascarenhas, MD; Naveen Pemmaraju, MD

$Cases and Conversations™: Sorting Through the Expanding Treatment Options for Patients with Relapsed/Refractory Multiple Myeloma$

Cases and Conversations™: Sorting Through the Expanding Treatment Options for Patients with Relapsed/Refractory Multiple Myeloma

C. Ola Landgren, MD, PhD; Mohamad Mohty, MD, PhD; Surbhi Sidana, MD

Medical Crossfire®: Precision Medicine in Glioma Treatment — Integration of Molecular Profiling to Inform Targeted Therapies

Medical Crossfire®: Precision Medicine in Glioma Treatment — Integration of Molecular Profiling to Inform Targeted Therapies

Vinay K. Puduvalli, MD; Manmeet Ahluwalia, MD, MBA; Stephen J. Bagley, MD, MSCE; Angela Waanders, MD, MPH, MS

PER Tumor Board®: Applying Recent Advances to Transform the Treatment Paradigm in SCLC—Expert Perspectives on New Approvals and Emerging Strategies

PER Tumor Board®: Applying Recent Advances to Transform the Treatment Paradigm in SCLC—Expert Perspectives on New Approvals and Emerging Strategies

Jonathan W. Goldman, MD; Percy Lee, MD, FASTRO; Erminia Massarelli, MD, PhD, MS; Misty D. Shields, MD, PhD

Evolving Treatment Strategies in Pancreatic Cancer: Current Standards, Emerging Targets, and the Role of Molecular Testing

Evolving Treatment Strategies in Pancreatic Cancer: Current Standards, Emerging Targets, and the Role of Molecular Testing

Eileen M. O’Reilly, MD; E. Gabriela Chiorean, MD, FASCO; Michael J. Pishvaian, MD, PhD; Brian Wolpin, MD, MPH

Cases & Conversations™: Transforming AML Care—Precision Strategies, Evolving Therapies, and Clinical Insights

Cases & Conversations™: Transforming AML Care—Precision Strategies, Evolving Therapies, and Clinical Insights

Gail J. Roboz, MD; Hagop Kantarjian, MD; Catherine Lai, MD, MPH; Amer Zeidan, MBBS, MHS

Tumor Board: Expert Insights on Managing Classical 𝘌𝘎𝘍𝘙 Mutations, 𝘌𝘎𝘍𝘙 Exon 20 Insertions, and Atypical 𝘌𝘎𝘍𝘙 Mutations in Metastatic NSCLC

Tumor Board: Expert Insights on Managing Classical 𝘌𝘎𝘍𝘙 Mutations, 𝘌𝘎𝘍𝘙 Exon 20 Insertions, and Atypical 𝘌𝘎𝘍𝘙 Mutations in Metastatic NSCLC

Balazs Halmos, MD, MS; Enriqueta Felip, MD, PhD; Julia Rotow, MD

Medical Crossfire®: Integrating Next-Generation Endocrine Targeting Therapies to Improve Outcomes for Patients With HR+/HER2- Breast Cancer

Medical Crossfire®: Integrating Next-Generation Endocrine Targeting Therapies to Improve Outcomes for Patients With HR+/HER2- Breast Cancer

William J. Gradishar, MD, FASCO, FACP; Laura Huppert, MD; Yuan Yuan, MD, PhD

Breast Cancer Tumor Board: Targeting TROP2 – Innovations in Triple-Negative Breast Cancer Treatment

Breast Cancer Tumor Board: Targeting TROP2 – Innovations in Triple-Negative Breast Cancer Treatment

Joyce O’Shaughnessy, MD; Matthew P. Goetz, MD; Hope S. Rugo, MD, FASCO

Dissecting Clinical Trial and Real-World Data for ADCs in TNBC

Dissecting Clinical Trial and Real-World Data for ADCs in TNBC

Filipa Lynce, MD; Rita Nanda, MD

Breaking Down the Rationale for Targeting TROP2 in TNBC

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Filipa Lynce, MD; Rita Nanda, MD

Cross-Disease Integration of Immunotherapy Innovations

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Ghassan Abou-Alfa, MD, MBA; Laura Williams Goff, MD, MSCI, MMHC, FASCO; Arndt Vogel, MD, PhD

PER Resource Center: Integrating Novel Approaches in TNBC – New Avenues for TROP2-Targeting ADCs and Beyond – Nursing

PER Resource Center: Integrating Novel Approaches in TNBC – New Avenues for TROP2-Targeting ADCs and Beyond – Nursing

Aditya Bardia, MD, MPH, FASCO; Erika P. Hamilton, MD; Virginia Kaklamani, MD, DSc; Filipa Lynce, MD; Rita Nanda, MD; Tiffany A. Traina, MD, FASCO

Medical Crossfire® in Adjunctive Testing: Charting a New Course in Prostate Cancer Risk Assessment

Medical Crossfire® in Adjunctive Testing: Charting a New Course in Prostate Cancer Risk Assessment

Jason Hafron, MD; Aaron D. Berger, MD; Arpeet Shah, MD

Community Practice Connections™: Enhancing Melanoma Outcomes With Intratumoral Oncolytic Immunotherapy–Strategies for the Multidisciplinary Team

Community Practice Connections™: Enhancing Melanoma Outcomes With Intratumoral Oncolytic Immunotherapy–Strategies for the Multidisciplinary Team

Yana G. Najjar, MD; Sapna Patel, MD

Community Practice Connections™: Optimizing SCLC Treatment Strategies and Managing Adverse Events Across Disease Stages

Community Practice Connections™: Optimizing SCLC Treatment Strategies and Managing Adverse Events Across Disease Stages

Erminia Massarelli, MD, PhD, MS; Misty D. Shields, MD, PhD

Navigating the Adverse Event Landscape in HER2+ GEA Therapy

Navigating the Adverse Event Landscape in HER2+ GEA Therapy

Rahul Gosain, MD, MBA; Rohit Gosain, MD; Geoffery Ku, MD; Shruti Patel, MD

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