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Evolving Treatment Strategies for Chronic Lymphocytic Leukemia: Insights From Experts Across Mayo Clinic Locations : Episode 7

Navigating Treatment Selection for CLL in the Relapsed/Refractory Setting

January 25, 2024
By Sameer A. Parikh, MD
Sikander Ailawadhi, MD
  • Mazie Tsang, MD, MAS, MS
  • Amber Koehler, PA-C, MS

Opinion
Video

A panel of oncology experts share their general approach in navigating treatment selection for patients with R/R CLL, highlighting key factors to consider in making treatment decisions.

EP: 1.Evolving Front-line Treatment Options for CLL

EP: 2.Navigating 1L Treatment Selection with BTKis in CLL

EP: 3.Updates on BTKi Monotherapy for CLL in the Frontline Setting

EP: 4.The Role of BTKi + Obinutuzumab for 1L Treatment of CLL

EP: 5.Expert Perspectives on Fixed Duration Therapy with Venetoclax + Obinutuzumab

EP: 6.Updates on Combination Treatment Approaches with BTKi + Venetoclax

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EP: 7.Navigating Treatment Selection for CLL in the Relapsed/Refractory Setting

EP: 8.Expert Insights on Extended Follow-Up Data from ALPINE and ELEVATE-RR

EP: 9.Consideration Factors in Treatment Selection for BTKi Therapy in R/R CLL

EP: 10.Key Considerations in Managing Hypertension Risk with BTKis in CLL

EP: 11.Expert Perspectives on Managing Risk of Atrial Fibrillation with BTKis in CLL

EP: 12.Managing Bleeding Risk in Patients with CLL on BTKi Therapy

EP: 13.Utilizing Real-World Data for Informed Decision-Making in CLL

EP: 14.Navigating Treatment Resistance and Sequencing in CLL

EP: 15.Advancements with Novel Treatment Approaches in CLL

EP: 16.Future Perspectives and Unmet Needs in CLL

Newsletter

Stay up to date on recent advances in the multidisciplinary approach to cancer.

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Recent Videos
Current findings from the phase 1/2 CaDAnCe-101 trial show no predictive factors of improved responses with BGB-16673 in patients with CLL or SLL.
More follow-up data will better elucidate the impact of frontline use of hypomethylating agents in patients with myelodysplastic syndromes.
Both clinicians and patients should have as much information as possible to participate in shared decision-making for CLL care, says Jacob D. Soumerai, MD.
Sequencing different treatments in the first 3 lines of therapy represents a challenge in chronic lymphocytic leukemia, according to Deborah Stephens, DO.
Compared with second-generation tyrosine kinase inhibitors, asciminib was better tolerated in patients with chronic myeloid leukemia.
Bulkiness of disease did not appear to impact PFS outcomes with ibrutinib plus venetoclax in the phase 2 CAPTIVATE study.
Greater direct access to academic oncologists may help address challenges associated with a lack of CAR T education in the community setting.
Certain bridging therapies and abundant steroid use may complicate the T-cell collection process during CAR T therapy.
Educating community practices on CAR T referral and sequencing treatment strategies may help increase CAR T utilization.
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