WASHINGTON--The FDA has approved QLT PhotoTherapeutics' light-activated drug Photofrin (porfimer sodium) for the palliative treatment of esophageal constriction in patients with advanced esophageal cancer.
WASHINGTON--The FDA has approved QLT PhotoTherapeutics' light-activateddrug Photofrin (porfimer sodium) for the palliative treatmentof esophageal constriction in patients with advanced esophagealcancer.
Photofrin is given intravenously, then activated by nonthermallight from a medical laser delivered via fiberoptic cables intothe esophagus. Once activated, the agent produces free radicalsthat help destroy cancer cells.
Studies showed that the treatment gave patients a higher qualityof life by allowing them to swallow again on their own.
QLT (Vancouver, BC) has entered into an agreement with New YorkCity-based Sanofi Winthrop to market Photofrin, the first formof photodynamic therapy (PDT) to receive FDA approval.
The FDA also granted marketing clearance to two laser systemsfor use with Photofrin: Coherent, Inc.'s Lambda Plus PDL.1 andPDL.2, and Laserscope's KTP/532 and KTP/YAG. A PDT Dye Moduleallows the Laserscope machines to be adapted for use in PDT.