Reading a Changed Eye Examination and Impact on Therapy

The faculty discuss a patient who feels well but whose eye examination has changed. One panelist explains that every patient needs a baseline eye evaluationfor visual acuity and corneal abnormalities, that simple punctate lesions are not absolute contraindications, and that steroid-related cataracts are better addressed before dosing so they do not confound visual acuity. Changes are typically seen after the second dose. For an asymptomatic grade 2 corneal abnormality, the dose is held,the eye is reassessed before the next scheduled dose, and dosing resumes once findings are back to baseline or grade 1, with a dose level reduction. The second panelist describes how the eye examination and the patient’s comfortimpact the interval.