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Opinion|Videos|September 8, 2023

The Evolving Landscape of Biomarker Testing in Metastatic Colorectal Cancer (mCRC)

Author(s)Tanios S. Bekaii-Saab, MD, FACP, Daniel Ahn, DO, Christina Wu, MB, BCh, MD

Daniel Ahn, DO, discusses the evolution of biomarker testing in metastatic colorectal cancer, highlighting the shift from understanding only the prognostic implications of genetic alterations to recognizing their predictive role in targeted therapies, and emphasizes the potential of circulating tumor DNA for rapid diagnosis and assessing treatment response.

Episodes in this series

EP. 1 An Overview of Colorectal Cancer (CRC)

EP. 1 An Overview of Colorectal Cancer (CRC)

EP. 2 The Evolving Landscape of Biomarker Testing in Metastatic Colorectal Cancer (mCRC)

EP. 2 The Evolving Landscape of Biomarker Testing in Metastatic Colorectal Cancer (mCRC)

EP. 3 Common Testing Strategies for Molecular Markers in mCRC

EP. 3 Common Testing Strategies for Molecular Markers in mCRC

EP. 4 Patient Scenario: A 65-Year-Old Man with HER2+ mCRC

EP. 4 Patient Scenario: A 65-Year-Old Man with HER2+ mCRC

EP. 5 MOUNTAINEER-01 Trial: Tucatinib in Patients With mCRC

EP. 5 MOUNTAINEER-01 Trial: Tucatinib in Patients With mCRC

EP. 6 DESTINY-CRC02 Trial: Trastuzumab Deruxtecan for the Management of mCRC

EP. 6 DESTINY-CRC02 Trial: Trastuzumab Deruxtecan for the Management of mCRC

EP. 7 Approaches for Treatment Sequencing in Patients With HER2+ mCRC

EP. 7 Approaches for Treatment Sequencing in Patients With HER2+ mCRC

EP. 8 Patient Scenario: A 66-Year-Old Male With BRAF-Mutant mCRC

EP. 8 Patient Scenario: A 66-Year-Old Male With BRAF-Mutant mCRC

EP. 9 The Role of BRAF in mCRC

EP. 9 The Role of BRAF in mCRC

EP. 10 BEACON Study: Encorafenib, Binimetinib, and Cetuximab in BRAF-Mutant mCRC

EP. 10 BEACON Study: Encorafenib, Binimetinib, and Cetuximab in BRAF-Mutant mCRC

EP. 11 BREAKWATER Study: Encorafenib, Cetuximab, and Chemotherapy for BRAF-Mutant mCRC

EP. 11 BREAKWATER Study: Encorafenib, Cetuximab, and Chemotherapy for BRAF-Mutant mCRC

EP. 12 The Future of BRAF-Mutant mCRC Management

EP. 12 The Future of BRAF-Mutant mCRC Management

EP. 13 Future CRC Treatment to Focus on Mutation Status, Expert Says

EP. 13 Future CRC Treatment to Focus on Mutation Status, Expert Says

Personalized therapy tailored for mutation status is something to expect in the coming years for colorectal cancer treatment, notes Tanios S. Bekaii-Saab, MD.

EP. 14 Tanios S. Bekaii-Saab, MD, Speaks to Expanding Horizons in CRC Treatment

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Breast Cancer Tumor Board: Targeting TROP2 – Innovations in Triple-Negative Breast Cancer Treatment

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Evaluating the Latest Data and Ongoing Trials for Novel ADC Approaches in TNBC

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Establishing the Rationale for ADC and ICI Combinations in TNBC

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Dissecting Clinical Trial and Real-World Data for ADCs in TNBC

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Optimizing Treatment for Biliary Tract Cancers

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Broadening the Frontline—Studies Informing the Use of Immunotherapy in Hepatocellular Carcinoma

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Cross-Disease Integration of Immunotherapy Innovations

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Expert Roundtable and Panel Discussions: Current and Future Landscape of TNBC

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Show Me the Data®: New and Emerging Roles for Oral SERD Therapy in the Treatment of ER+/HER2– Breast Cancer

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Practical Considerations and Future Directions for New Treatment Strategies in SCLC

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PER Resource Center: Integrating Novel Approaches in TNBC – New Avenues for TROP2-Targeting ADCs and Beyond – Nursing

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Radioligand Therapy 101: The Science Behind the Strategy

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Working Together: Overcoming Barriers to Optimize Outcomes in Patients Treated With Radioligand Therapy Through Multidisciplinary Care

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21st Annual New York Lung Cancers Symposium®

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Navigating the Adverse Event Landscape in HER2+ GEA Therapy

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Medical Crossfire® in Adjunctive Testing: Charting a New Course in Prostate Cancer Risk Assessment

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Community Practice Connections™: Enhancing Melanoma Outcomes With Intratumoral Oncolytic Immunotherapy–Strategies for the Multidisciplinary Team

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