Final overall survival and the association of pathological outcomes with event-free survival in MATTERHORN: A randomised, phase 3 study of durvalumab plus 5-fluorouracil, leucovorin, oxaliplatin and docetaxel in resectable gastric / gastroesophageal junction adenocarcinoma

EP. 1: Selecting Neoadjuvant Strategies for Esophageal and GEJ Adenocarcinoma Across Multidisciplinary Practices
ByRutika Mehta, MD, MPH,Sharon Shiraga, MD, FACS,Sreenivasa R. Chandana, MD, PhD,Jacques-Pierre Fontaine, MD Experts discuss tailored approaches to neoadjuvant therapy for esophageal and G-junction cancers, emphasizing the importance of multidisciplinary care.

EP. 2: Current Standards in Resectable Gastric and GEJ Adenocarcinoma: Multidisciplinary Perspectives on Perioperative Management
ByRutika Mehta, MD, MPH,Sharon Shiraga, MD, FACS,Sreenivasa R. Chandana, MD, PhD,Jacques-Pierre Fontaine, MD Explore the evolving landscape of cancer treatment strategies, focusing on guideline-based management and the impact of multimodal approaches on patient outcomes.

EP. 3: Evaluating Total Neoadjuvant Approaches: Balancing Treatment Intensity, Surgical Timing, and Patient Selection
ByRutika Mehta, MD, MPH,Sharon Shiraga, MD, FACS,Sreenivasa R. Chandana, MD, PhD,Jacques-Pierre Fontaine, MD Experts discuss tailored approaches to neoadjuvant therapy for esophageal and gastroesophageal junction cancers, emphasizing multidisciplinary care and surgical precision.

EP. 4: Managing FLOT Tolerability, Assessing Pathologic Response, and Addressing Unmet Needs in the Perioperative Setting
ByRutika Mehta, MD, MPH,Sharon Shiraga, MD, FACS,Sreenivasa R. Chandana, MD, PhD,Jacques-Pierre Fontaine, MD Experts discuss the challenges and strategies in managing patients with inadequate responses to preoperative cancer treatments, emphasizing the need for clinical trials.

A panel of experts gathered to discuss results from the MATTERHORN trial assessing durvalumab plus FLOT in gastric/GEJ cancer.

EP. 6: MATTERHORN Trial Design and DFLOT Adoption: Integrating Immunotherapy Into Perioperative Practice
ByRutika Mehta, MD, MPH,Sharon Shiraga, MD, FACS,Sreenivasa R. Chandana, MD, PhD,Jacques-Pierre Fontaine, MD Experts discuss the challenges and strategies in managing patients with inadequate responses to preoperative cancer treatments, emphasizing the need for clinical trials.

EP. 7: DFLOT Implementation: Surgical Timing, Patient Selection, and the Evolving Role of Adjuvant Immunotherapy
ByRutika Mehta, MD, MPH,Sharon Shiraga, MD, FACS,Sreenivasa R. Chandana, MD, PhD,Jacques-Pierre Fontaine, MD Doctor Fontaine discusses the importance of patient selection for preoperative chemotherapy and the effectiveness of immune checkpoint inhibitors in surgery outcomes.

EP. 8: Interpreting Endpoints and Pathologic Response: Applying EFS, PCR, and Biomarkers in Perioperative Decision Making
ByRutika Mehta, MD, MPH,Sharon Shiraga, MD, FACS,Sreenivasa R. Chandana, MD, PhD,Jacques-Pierre Fontaine, MD Experts discuss the significance of event-free survival and overall survival in cancer trials, emphasizing the importance of patient quality of life.

EP. 9: Interpreting Overall Survival and Subgroup Outcomes in MATTERHORN: Where DFLOT Shows Strength and Where Questions Remain
ByRutika Mehta, MD, MPH,Sharon Shiraga, MD, FACS,Sreenivasa R. Chandana, MD, PhD,Jacques-Pierre Fontaine, MD Experts discuss the significance of event-free survival and overall survival in cancer trials, emphasizing patient quality of life and treatment decisions.

EP. 10: Integrating PD-L1 Testing and Practical Implications for DFLOT Adoption
ByRutika Mehta, MD, MPH,Sharon Shiraga, MD, FACS,Sreenivasa R. Chandana, MD, PhD,Jacques-Pierre Fontaine, MD Experts discuss the importance of PD-L1 testing in treatment decisions for gastric cancer, emphasizing personalized approaches and improved patient outcomes.

EP. 11: Counseling Patients on PCR, Residual Disease, and the Role of Adjuvant Therapy After DFLOT
ByRutika Mehta, MD, MPH,Sharon Shiraga, MD, FACS,Sreenivasa R. Chandana, MD, PhD,Jacques-Pierre Fontaine, MD Oncologists discuss the significance of PCR and MPR rates in patient counseling, emphasizing treatment benefits and survival outcomes.

EP. 12: Strengths, Limitations, and Real World Adoption of the MATTERHORN DFLOT Strategy
ByRutika Mehta, MD, MPH,Sharon Shiraga, MD, FACS,Sreenivasa R. Chandana, MD, PhD,Jacques-Pierre Fontaine, MD Experts discuss the strengths and limitations of the Matterhorn study, highlighting advancements in immunotherapy for upper GI cancer and future research directions.

EP. 13: Applying DFLOT to a Real World Case of Resectable Stage III GE Junction Cancer
ByRutika Mehta, MD, MPH,Sharon Shiraga, MD, FACS,Sreenivasa R. Chandana, MD, PhD,Jacques-Pierre Fontaine, MD Explore the complexities of managing a Stage 3 gastric adenocarcinoma case, focusing on surgical options and perioperative treatment strategies.

EP. 14: Managing Toxicity, Monitoring Needs, and Logistical Realities of DFLOT in Perioperative Care
ByRutika Mehta, MD, MPH,Sharon Shiraga, MD, FACS,Sreenivasa R. Chandana, MD, PhD,Jacques-Pierre Fontaine, MD Experts discuss the management of immune-mediated side effects in perioperative cancer treatment, emphasizing patient care and monitoring strategies.

EP. 15: Ensuring Comprehensive Support and Long Term Success for Patients Receiving DFLOT
ByRutika Mehta, MD, MPH,Sharon Shiraga, MD, FACS,Sreenivasa R. Chandana, MD, PhD,Jacques-Pierre Fontaine, MD Discover how specialized cancer care, including nurse navigators and telehealth, enhances patient outcomes and quality of life post-treatment.