Ahmad A. Tarhini, MD, PhD | Authors

Using Genomic Sequencing to Improve Management in Melanoma

March 15, 2018

Here we summarize the available genomic and genetic tests for melanoma, and the level of evidence supporting each of these. We also discuss the current impact of genomic sequencing on the management of melanoma, as well as roles it may play in the near future.

Developments in the Screening and Prognostication of Melanoma

June 08, 2017

This peer-to-peer discussion reviews the current strategies for managing patients with melanoma, including screening and prognosis for high-risk patients and how to choose the best therapies to avoid toxicities and treatment resistance.

The Future of Systemic Therapy of Melanoma: Combinations, Predictive Biomarkers

February 15, 2015

While the last several decades saw a lack of progress in treatment outcomes in this setting, the outlook has recently changed dramatically, driven by a deepening understanding of melanoma biology and host immunology.

CTLA-4–Blocking Immunotherapy With Ipilimumab for Advanced Melanoma

December 15, 2010

Each year, nearly 60,000 new cases of melanoma are reported in the United States. The vast majority of these are cured by surgery. However, 8,000 of these patients are found to have metastatic melanoma beyond the scope of surgical cure-and this number closely approximates the annual number of deaths from this disease. This statistic illustrates the lack of progress that had been made in the treatment of advanced melanoma over the last several decades.

Despite Past Disappointments the Future of Melanoma Therapy Appears Bright

May 20, 2009

Annually, about 8,000 patients are found to have metastatic melanoma presenting as recurrence of an earlier primary melanoma, and this number closely approximates the annual number of deaths from the disease. This statistic illustrates the lack of progress that has been made in the treatment of stage IV melanoma over the past several decades.