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Opinion|Videos|June 6, 2025

Navigating Newer Treatment Regimens in Melanoma: Practical Approaches to Dosing and Adverse Event Management

Author(s)Douglas B. Johnson, MD, MSCI, Ahmad A. Tarhini, MD, PhD, Yana G. Najjar, MD

Panelists discuss how community oncologists have developed good experience managing immune-related adverse events and are increasingly adopting relatlimab-nivolumab due to its lower toxicity profile and convenient administration schedule of half-hour infusions every four weeks.

Episodes in this series

EP. 1 The Evolving Treatment Paradigm in Melanoma: Targeted Therapy vs Immunotherapy

EP. 1 The Evolving Treatment Paradigm in Melanoma: Targeted Therapy vs Immunotherapy

EP. 2 Frontline Treatment Options for Melanoma

EP. 2 Frontline Treatment Options for Melanoma

EP. 3 Clinical Perspectives: Single-Agent Vs Combination Immunotherapy for Melanoma

EP. 3 Clinical Perspectives: Single-Agent Vs Combination Immunotherapy for Melanoma

EP. 4 Combination Immunotherapy Strategies in Melanoma: Insights From Key Trials

EP. 4 Combination Immunotherapy Strategies in Melanoma: Insights From Key Trials

EP. 5 Managing Expectations: Adverse Events With Melanoma Immunotherapy

EP. 5 Managing Expectations: Adverse Events With Melanoma Immunotherapy

EP. 6 Immunotherapy Dosing Strategies: Optimizing Efficacy and Managing Toxicity in Melanoma

EP. 6 Immunotherapy Dosing Strategies: Optimizing Efficacy and Managing Toxicity in Melanoma

EP. 7 Balancing Efficacy and Safety: Toxicity Considerations With Melanoma Immunotherapy

EP. 7 Balancing Efficacy and Safety: Toxicity Considerations With Melanoma Immunotherapy

EP. 8 Navigating Newer Treatment Regimens in Melanoma: Practical Approaches to Dosing and Adverse Event Management

EP. 8 Navigating Newer Treatment Regimens in Melanoma: Practical Approaches to Dosing and Adverse Event Management

EP. 9 Sequencing Melanoma Treatments: Strategies for Optimizing Patient Outcomes

EP. 9 Sequencing Melanoma Treatments: Strategies for Optimizing Patient Outcomes

EP. 10 Looking Ahead: What’s on the Horizon in Advanced Melanoma

EP. 10 Looking Ahead: What’s on the Horizon in Advanced Melanoma

Adoption of Newer Immunotherapy Regimens

Key Discussion Points:

Community adoption of newer immunotherapy combinations
Evidence-based decision-making in regimen selection
Factors influencing uptake of nivolumab/relatlimab in clinical practice

Key Points for Physicians:

Long-term efficacy data from CheckMate 067 continues to influence treatment selection, though growing confidence in nivolumab/relatlimab is emerging with longer follow-up
Practical advantages of nivolumab/relatlimab include its 30-minute infusion every 4 weeks schedule and improved toxicity profile
Pathways and prescribing protocols generally allow flexibility in selecting between available immunotherapy regimens

Notable Insights:

Community oncologists typically prioritize evidence-based decision-making, with increasing comfort using nivolumab/relatlimab as longer-term efficacy data becomes available, including the recent 4-year follow-up and indirect treatment comparison data.

Clinical Significance:

Adoption of newer immunotherapy combinations is primarily driven by accumulating efficacy data and real-world experience, with treatment selection ultimately guided by individual patient factors and physician experience with managing toxicities.

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