Author | Gary P. Engstrom, MD

Articles

Hodgkin's Disease

April 01, 2005

ByGary P. Engstrom, MD|David B. Sanford, MD|Fredrick B. Hagemeister, MD

Although there have been many advances in the treatment of Hodgkin's disease, diagnosis of the disease still rests on the identification of the Reed-Sternberg cell. This distinctive, though nonspecific, cell was first described by Sternberg in 1898 and further elucidated by Reed in 1902. In most biopsies, the Reed-Sternberg cell accounts for only 1% of the cells present, with the remainder consisting of lymphocytes, granulocytes, histiocytes, plasma cells, and fibroblasts