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Guru Subramanian Guru Murthy, MD, MS

Articles by Guru Subramanian Guru Murthy, MD, MS

Patient Case Presentation: Patient on ESA for First-Line Therapy and Not Receiving a Marked Response—What Do You Do Next, and Why?

ByThomas W. LeBlanc, MD, MA,Guru Subramanian Guru Murthy, MD, MS, Raji Shameem, MD,Daniel DeAngelo, MD, PhD,Rafael Madero-Marroquin, MD,Mikkael A. Sekeres, MD, MS

Panelists discuss management strategies for a patient with low-risk myelodysplastic syndrome with erythropoiesis-stimulating agent (ESA) failure, weighing options between initiating luspatercept or escalating ESA dosage while emphasizing the need for thorough evaluation of reversible causes before advancing therapy.

Patient Case Presentation: Patient Is RBC Transfusion Eligible—Would You Proceed to Transfusion or Initiate Long-Term Anemia Treatment Strategies?

ByThomas W. LeBlanc, MD, MA,Guru Subramanian Guru Murthy, MD, MS, Raji Shameem, MD,Daniel DeAngelo, MD, PhD,Rafael Madero-Marroquin, MD,Mikkael A. Sekeres, MD, MS

Panelists discuss a complex case of lower-risk myelodysplastic syndrome in a patient with rheumatoid arthritis, debating immediate transfusion for symptom relief vs thorough evaluation and targeted long-term anemia management to balance comorbidities and optimize outcomes.

Debate: Sequencing Therapies for LR-MDS: ESA First vs Luspatercept First

ByThomas W. LeBlanc, MD, MA,Guru Subramanian Guru Murthy, MD, MS, Raji Shameem, MD,Daniel DeAngelo, MD, PhD,Rafael Madero-Marroquin, MD,Mikkael A. Sekeres, MD, MS

Panelists discuss the sequencing of therapies in lower-risk myelodysplastic syndromes, debating whether to initiate treatment with erythropoiesis-stimulating agents due to cost and patient variability or with luspatercept for its superior efficacy and potential disease-modifying effects, while highlighting ongoing trials exploring combined or sequential strategies.

Debate: Inflection Point for LR-MDS Therapy: Serum EPO >200 U/L vs Serum EPO >500 U/L

ByThomas W. LeBlanc, MD, MA,Guru Subramanian Guru Murthy, MD, MS, Raji Shameem, MD,Daniel DeAngelo, MD, PhD,Rafael Madero-Marroquin, MD,Mikkael A. Sekeres, MD, MS

Panelists discuss treatment strategies for lower-risk myelodysplastic syndromes guided by serum erythropoietin (EPO) levels, weighing the reduced efficacy of erythropoiesis-stimulating agents at higher EPO levels against newer therapies’ benefits and challenges, and emphasizing personalized sequencing based on patient and disease characteristics.

Debate: Optimal Initiation of ESAs, Luspatercept, and Imetelstat: Pretransfusion vs Posttransfusion

ByThomas W. LeBlanc, MD, MA,Guru Subramanian Guru Murthy, MD, MS, Raji Shameem, MD,Daniel DeAngelo, MD, PhD,Rafael Madero-Marroquin, MD,Mikkael A. Sekeres, MD, MS

Panelists discuss the debate on optimal timing for initiating therapies in lower-risk myelodysplastic syndromes, balancing early intervention to improve quality of life and prevent complications against a conservative approach favoring treatment initiation upon transfusion dependency or symptom onset.

COMMANDS and ELEMENT-MDS Trials: Long-Term Analysis, Survival, Duration of Response, and Hemoglobin Levels

ByThomas W. LeBlanc, MD, MA,Guru Subramanian Guru Murthy, MD, MS, Raji Shameem, MD,Daniel DeAngelo, MD, PhD,Rafael Madero-Marroquin, MD,Mikkael A. Sekeres, MD, MS

Panelists discuss long-term results from a phase 3 trial comparing luspatercept and epoetin alfa in lower-risk MDS, highlighting luspatercept’s superior efficacy in achieving sustained transfusion independence and the need for further research on earlier intervention strategies.

Early vs Late Onset of ESA in LR-MDS: Results From Phase 3 EPO-PRETAR Trial

ByThomas W. LeBlanc, MD, MA,Guru Subramanian Guru Murthy, MD, MS, Raji Shameem, MD,Daniel DeAngelo, MD, PhD,Rafael Madero-Marroquin, MD,Mikkael A. Sekeres, MD, MS

Panelists discuss the results of the phase 3 EPO-PRETAR trial in a dynamic, debate-style forum on lower-risk myelodysplastic syndromes, weighing the benefits of early vs late erythropoiesis-stimulating agent initiation while highlighting the need for more patient-centered outcome measures.

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