Ian A. Cree, PhD

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Continuous Low-Dose GM-CSF as Salvage Therapy in Refractory Recurrent Breast or Female Genital Tract Carcinoma

Christian M. Kurbacher, MD, PhD;Jutta A. Kurbacher, MD;Eva-maria Cramer, MD;Kerstin Rhiem, MD;Peter K. Mallman, MD, PhD;Ralf Reichelt, PhD;Uwe Reinhold, MD, PhD;Ursula Stier, MD;Ian A. Cree, PhD
April 2nd 2005

Granulocyte-macrophage colony-stimulating factor (GM-CSF,sargramostim [Leukine]) is a powerful cytokine that is able to stimulatethe generation of dendritic cells. Adjuvant treatment with continuous lowdoseGM-CSF has been shown to prolong survival of stage III/IV melanomapatients. Data on continuous low-dose GM-CSF therapy in tumorsother than prostate cancer are still lacking.

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