Articles by Pierre Kerbrat, MD
UFT/Leucovorin Plus Vinorelbine Combination for Advanced Breast Cancer
ByPierre Fumoleau, MD,Régine Déporte, PhD,Pierre Kerbrat, MD,Jacques M. Bonneterre, MD, PhD,Pierre Fargeot, MD This phase I study was undertaken to define the maximum tolerated dose, the dose-limiting toxicity, and the recommended dose of UFT plus leucovorin and vinorelbine in combination treatment of patients with metastatic breast cancer previously treated with one chemotherapy regimen. The pharmacokinetics of UFT and vinorelbine were also evaluated.
This phase I study was undertaken to define the maximum tolerated dose, dose-limiting toxicity, and recommended dosage of UFT (uracil and tegafur) plus oral calcium folinate (Orzel) and vinorelbine (Navelbine) in
