57 Altered Biomechanics Drives Outcome in Breast Cancer: A New Avenue for Oncology Biomarkers
BySara Nizzero,Mariam Gachechiladze,Gregory Zaugg,Licheng Zhang,Yitian Xu,María José Peláez Soní,Brian A. Menegaz,Lee B. Jordan,Colin A. Purdie,Philip R. Quinlan,Chandandeep Nagi,Karla A. Sepulveda,Philipp Oertle,Tobias A. Appenzeller,Shu-Hsia Chen,Marko Loparic,Zhihui Wang,Vittorio Cristini,Marija Plodinec,Alastair M. Thompson
Using spatial proteomics and nanomechanical profiling across two clinical cohorts, investigators identified hypoxia-driven epithelial-to-mesenchymal transition as a biological signature linking aggressive biomechanical phenotypes to poor breast cancer outcomes.