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We know that breast cancer represents a spectrum of diseases, with variation in prognosis, and that RT can range from highly complex treatments to the breast and regional lymph nodes, to complete avoidance of radiation.

To paraphrase a deep philosophical question: if an important, long-awaited phase III prospective randomized trial from Europe is published and no one pays attention, does it make a sound?

A small study found that it is feasible to detect BRCA1/2 reversion mutations in circulating cell-free DNA in patients with recurrent high-grade serous ovarian cancer. Those reversion mutations can help predict poor response to therapy in these patients.

A genomic analysis of Ewing sarcoma found substantial epigenetic heterogeneity both between tumors and within tumors, highlighting the need to consider non-genetic aspects in cancer biology and treatment.

Are you up to date on adverse prognostic factors for Ewing sarcoma? Do you know the latest drug approved for metastatic soft-tissue sarcoma? Test your knowledge on sarcoma in our latest quiz.

This video with Stacy Moulder, MD, highlights efforts to identify various subtypes and molecular targets in triple-negative breast cancer, which could lead to treatment options with already approved agents.

Oncologists deliver news-good and bad-on a daily basis. It is, for me, the most challenging and rewarding part of my job.

What clinical risk factor has been found to be most prevalent for both premenopausal and postmenopausal women? What population sees a benefit of oophorectomy for preventing breast cancer? Test your knowledge in our latest quiz.

This video examines a study that looked at whether aromatase inhibitors are associated with higher myocardial infarction risk in breast cancer patients.

Use of communication coaching that included a question prompt list-or structured lists of questions given to patients prior to consultations-helped patients with advanced cancer and their caregivers to bring up topics of concern during oncology office visits.

Most patients with cancer decreased their physical activity levels following their diagnosis, in spite of the potential benefits associated with exercise, according to a new study.

Anxiety is common among partners of young breast cancer survivors, even several years after the diagnosis, according to a new analysis. Anxiety was correlated with the use of less constructive and more maladaptive coping strategies.

Adjuvant chemotherapy for biliary tract cancer using GEMOX (gemcitabine/oxaliplatin) was feasible, but did not result in an improved recurrence-free survival or quality of life compared with surveillance in the phase III PRODIGE 12-ACCORD 18 trial.

Use of stereotactic body radiation therapy (SBRT) was equally effective as transarterial chemoembolization (TACE) as a method of bridge to transplant among patients with hepatocellular carcinoma.

This video examines an exploratory analysis of the RESORCE trial, which tested regorafenib vs placebo in hepatocellular carcinoma patients following radiographic progression on sorafenib.

The majority of hematologist-oncologists who use the social media platform Twitter had some financial conflict of interest, according to new data.

This video examines findings from the International Breast Cancer Intervention Study (IBIS-1), which found that patients with menopause symptoms were less likely to continue long-term tamoxifen therapy.

This video looks at a new study that found that in addition to conferring resistance to hormone therapies, estrogen receptor mutations can cause breast cancer cells to metastasize.

The use of mammography, but not colonoscopy, has increased in the post–Affordable Care Act years, which eliminated out-of-pocket expenditures for these recommended services, according to the results of a new study.

Breast cancer screening was not associated with any reduction in the incidence of advanced cancer, and overdiagnosis of invasive tumors and ductal carcinoma in situ is a common problem, according to a new study conducted in Denmark.

The FDA has concluded that pioglitazone, used to treat type 2 diabetes, may be linked to an increased risk of bladder cancer.

Among cancer patients with bone metastases, administration of zoledronic acid every 12 weeks did not increase the risk of skeletal events over 2 years compared with the standard dosing of every 4 weeks.

An increasing percentage of men over the age of 75 who are diagnosed with prostate cancer have distant metastases at the time of diagnosis, according to a new study.

Soft-tissue sarcomas account for about 1% of all adult and 15% of all pediatric malignancies. To date, more than 50 different histologic subtypes have been identified. Test your knowledge about sarcoma in our latest quiz.

Do you know the most important risk factor in urothelial cancers? How about testicular cancer patients’ risk of developing cancer in the opposite testicle? Test your knowledge on these topics and more in our latest quiz.

The FDA has approved a new device that allows for the expansion of soft tissue in two-stage breast reconstruction surgery conducted after mastectomy.

This slide show highlights some of the most read stories on Cancer Network in 2016, including guidelines on surgical margins in DCIS, a study on serum vitamin D levels in breast cancer patients, and more.

Are we failing to be as efficient as we could be in delivering care to cancer patients, particularly in follow-up after treatment?

Do you know the median survival of different risk groups for patients with multiple myeloma? How about the recommended frequency to observe patients with smoldering myeloma? Test your knowledge on these topics and more in our latest quiz.

The antioxidant sodium thiosulfate protects children and adolescents against cisplatin-induced hearing loss without any added serious adverse effects, according to a randomized study.