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recent teleconference sponsored by Cancer Care Inc centered on newer treatments for aggressive lymphomas. Michael Grossbard, MD,

The increasing use of systemic and directed liver therapy for patients with hepatic metastases has created a demand for improved accuracy of noninvasive imaging techniques. Computed tomography (CT) and magnetic

The management of hepatic tumors presents a challenging problem. The natural history of primary and metastatic liver lesions portends a poor prognosis. However, surgical resection and newer ablative techniques have had a

NEW YORK-Coping with cancer and the side effects of treatment can be difficult and frustrating for caregivers as well as patients. Frances K. Barg, MEd, Coordinator for Cancer Control Education, University of Pennsylvania School of Nursing, and Mary Pat Lynch, CRNP, MSN, AOCN, graduate faculty, Oncology Advanced Practice Nurse Program, University of Pennsylvania School of Nursing, had some tips for caregivers and answers to their questions at a Cancer Care, Inc. teleconference. They reviewed a number of things caregivers can do to help relieve the most common problems.

Hepatocellular carcinoma (HCC) is one of the world’s most common cancers. It is closely associated with cirrhosis, especially that due to viral hepatitis. The incidences of viral hepatitis and HCC are rising steadily in the United

Kaposi’s sarcoma (KS) is the most common malignancy associated with the acquired immunodeficiency syndrome (AIDS). Recent years have witnessed a decline in the overall incidence of AIDS-related KS, as well as a greater

In this short review, we describe two new liver-specific contrast agents for MRI that are in clinical development. The main differences among the liver-specific contrast agents available at present are also discussed briefly.

edicare has scheduled a national meeting on self-injectable drugs for May 18 in Baltimore. The meeting comes

WASHINGTON-All cancer patients should have the opportunity to participate in clinical trials, something that will occur only if Congress passes pending legislation to guarantee insurance coverage for the cost of routine patient care for study participants, speakers told a Capitol Hill briefing sponsored by the American Society of Clinical Oncology (ASCO).

NEW ORLEANS-Mastectomy patients who have undergone radiation therapy can still have attractive results from breast reconstruction, providing the surgeon does not underestimate the extent of reconstruction required, according to results of a prospective study presented at the 68th Annual Scientific Meeting of the American Society of Plastic and Reconstructive Surgeons

The US Food and Drug Administration’s (FDA) Oncologic Drugs Advisory Committee (ODAC) recently voted to support approval of gemtuzumab ozogamicin (Mylotarg) for the treatment of patients ³ 60 years old with CD33-positive, relapsed

MUNICH, Germany-Patients with low-grade lymphoma had a longer disease-free interval when they received radiochemotherapy and stem cell transplant than when they were maintained on interferon-alfa, Wolfgang Hiddemann, MD, PhD, said at the American Society of Hematology annual meeting.

DALLAS-A preclinical study suggests that adding fish oil to the diet of a cancer patient might increase the effectiveness of cancer therapies and improve the patient’s outcome, W. Elaine Hardman, PhD, of the University of Texas Health Science Center at San Antonio, said at the Susan G. Komen Foundation’s 1999 National Grant Conference.

NEW YORK-“Brain metastases are like orphans when it comes to medical specialties. They really do not belong to any particular area,” said Raymond Sawaya, MD, professor and chair of neurosurgery, M.D. Anderson Cancer Center. But evaluation and treatment are improving, he told patients taking part in a teleconference sponsored by the National Brain Tumor Foundation, Cancer Care, Inc., and the Oncology Nursing Society.

WASHINGTON-While acknowledging that tobacco is a major health problem, the Supreme Court has rejected the Clinton Administration’s efforts to create a new federal control effort. It ruled 5 to 4 that “Congress has clearly precluded the Food and Drug Administration (FDA) from asserting jurisdiction to regulate tobacco products.”

ORLANDO-“There are still too many rectums being removed in patients with invasive rectal cancer,” said W. Robert L. Rout, MD, associate professor of surgery, University of Florida, Gainesville. He believes this situation could be improved with the use of preoperative radiotherapy and chemotherapy.

WASHINGTON-Ethnic and racial disparities in health care are too often the result of racism, said Thomas Perez, director of the Office for Civil Rights in the US Department of Health and Human Services. He was one of a number of speakers at the 7th Biennial Symposium on Minorities, the Medically Underserved, and Cancer.

ROCKVILLE, Md-Stung by the failure of several researchers to fully comply with federal gene therapy rules and reporting procedures, the Food and Drug Administration (FDA) and the National Institutes of Health (NIH) have taken a series of steps to tighten the control and monitoring of such trials.

PITTSBURGH-The National Surgical Adjuvant Breast and Bowel Project (NSABP) is encouraging women from racial and ethnic minority groups to consider joining the group’s Study of Tamoxifen and Raloxifene (STAR).

FT. LAUDERDALE, Fla-Treatment pathways describing when and how to titrate short-acting opioids rapidly are now part of the National Comprehensive Cancer Network (NCCN) Practice Guidelines for Cancer Pain.

Patients who have newly diagnosed leukemia are often overwhelmed with the complexities of their disease and its required therapy. In their book, Understanding Leukaemia and Related Cancers, Drs. Mughal and Goldman offer patients a

The House Judiciary Committee overwhelmingly approved what has been a controversial bill (H.R. 1304) allowing independent physicians in a given community to negotiate jointly with a managed care plan. Doing so is currently against

FORT LAUDERDALE, Florida-When managed care companies deny reimbursement for care decided upon by the physician and patient, have they crossed the line from managing medical care to practicing medicine? A panel of physicians, lawyers, patient advocates, and representatives from managed care held forth on this issue at a roundtable held during the Fifth Annual Conference of the National Comprehensive Cancer Network (NCCN).

SAN DIEGO-External magnets are being used to guide a novel, intra-arterially administered chemotherapy delivery vehicle directly to the tumor site (see illustration ). Scott C. Goodwin, MD, chief of vascular and interventional radiology, UCLA Medical Center, reported results of an ongoing phase I/II study of this new regional therapy technique at the annual scientific meeting of the Society of Cardiovascular & Interventional Radiology.

NEW ORLEANS-Pathologic examination of an intraoperative frozen section of the sentinel lymph node (SLN) is less sensitive for breast cancer patients with smaller tumors and/or micrometa-static disease. In a recent study, use of routine frozen section avoided reoperation in only 4% of patients with T1a cancers, but was more useful in other stages, reported Martin R. Weiser, MD, of Memorial Sloan-Kettering Cancer Center.

The National Library of Medicine has started posting information about clinical trials in its new Clinical Trials

WASHINGTON-The ongoing revolution in knowledge about the cellular processes that lead to cancer has created a new and potentially far more efficient approach to finding effective therapeutic agents, said Edward A. Sausville, MD, PhD, associate director of the NCI’s Developmental Therapeutics Program.

BETHESDA, Md-Officials of the National Cancer Institute (NCI) and the Centers for Disease Control and Prevention (CDC) have signed a formal agreement to develop what NCI calls “a comprehensive, federally integrated cancer surveillance and cancer control research system.” The two agencies will pool and jointly release their data on cancer incidence and mortality, as well as coordinate various aspects of cancer registry management, including training and methodology development.

To assist in converting patients from one opioid agent to another in their daily practice, many oncologists carry pocket dosage conversion guides based on package inserts approved by the US Food and Drug Administration (FDA). One such guide issued by the manufacturer of transdermal fentanyl (Duragesic), reproduced in Table 3 of the expert consensus article written by Breitbart et al, presents the equivalent of 25 µg/h of transdermal fentanyl as 45 to 134 mg/d of oral morphine. In another guide, distributed by one of the manufacturers of controlled-release morphine, the 25 µg/h strength of transdermal fentanyl is said to be equianalgesic to 15 mg of controlled-release morphine administered every 12 hours (and both are deemed equivalent to 10 mg of controlled-release oxycodone every 12 hours). Faced with such a wide range of conversion factors, it is of little surprise-as Breitbart et al point out-that clinicians often fail to achieve equianalgesia when converting patients from one opioid to another.

The two research groups from Long Island Jewish Medical Center and Yale University have collaborated to write an excellent overview of the biological basis of radio-sensitivity, especially as it applies to radiotherapy. The content of the paper reflects the excellence of these investigators’ contributions to the field of radiobiology. It is particularly refreshing to read an account of radiobiology that does not resort to the mathematical overanalysis that has plagued the field in the past.