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The last decade has seen a dramatic increase in the availability of nonopioid analgesics for the management of chronic pain. The change has been especially great in the area of adjuvant analgesics, the diverse group of drugs that have other primary

SEATTLE--The two studies most often cited as proof that psychological support can improve survival in cancer patients came under challenge at the annual meeting of the American Association for the Advancement of Science.

Patients with cancer have a significant risk for infection due to their treatment with chemotherapy, radiation, or surgery," stated Debra Wujcik, RN, MSN, AOCN, clinical director at Vanderbilt Cancer Center in Nashville, Tennessee, at the 1996

FORT LAUDERDALE, Fla--Writing guidelines for cancer screening that include genetic testing--the next major guidelines initiative for the National Comprehensive Cancer Network (NCCN)--will be complex because "every cancer, every gene linked to a cancer, and every patient situation is going to present different kinds of problems," Henry Greely, JD, said at the NCCN's second annual conference.

SAN DIEGO--Research involving telomerase, the protein thought to be responsible for cancer cell immortality, is experiencing explosive growth, and nowhere was that more evident than at the annual meeting of the American Association for Cancer Research (AACR).

Although it is clear that diet plays a role in the etiology of many cancers, making dietary recommendations to reduce risk is highly complicated, if, indeed, it is possible at all, according to an international cancer prevention expert. With 30% to 50%

SAN DIEGO--The bcl-2 gene, present in follicular-type B cell lymph-oma, serves as a critical checkpoint in the apoptosis pathway, and may be involved in the development of ultraviolet-induced skin cancers, in combination with the tumor-suppressor gene p53, according to two reports presented at the American Association for Cancer Research (AACR) annual meeting.

ROCHESTER, NY--The WHO International Network for Cancer Education (INCE) has joined with its first partner, the American Association for Cancer Education (AACE), to put together an international traveling exhibit of educational materials and resources for cancer education, to be shown at many of the smaller cancer congresses around the world, Charles D. Sherman, Jr., MD, told Oncology News International.

NEW YORK--Pain is highly prevalent in patients with HIV disease. Yet clinicians are often afraid to prescribe opioids when the patient is a former substance abuser, William Breitbart, MD, said at a conference on chemical dependency and pain management.

NEW YORK--About 60% of the US population dies in the hospital, and many have questioned whether hospitals are the best place to care for the dying. However, the hospital setting offers many advantages, Myra Glajchen, DSW, said during a teleconference sponsored by Cancer Care Inc.

Mycobacterial cell wall therapy may be an alternative to BCG in the treatment of carcinoma in situ (CIS) of the bladder, Dr. Alvaro Morales, of Queen's University, Kingston, Ontario, reported at the AUA meeting.

ROCKVILLE, Md--Last year, the National Cancer Institute established the Office of Cancer Survivorship, and NCI director Richard D. Klausner, MD, named Anna T. Meadows, MD, to head its efforts to explore issues of the physical, psychological, and economic well being of cancer patients.

NEW YORK--A hospice is not a place but, rather, a point of view, Paul Brenner, MDiv, said during a teleconference sponsored by Cancer Care Inc. "Hospice care can take place in different settings: home, hospital, or hospice," he said. It is hospice's fundamental assumption--that the end of life is a normal and valued part of human development--that sets it apart from other health care services.

SAN DIEGO--Genetically engineered bacteria have the potential to deliver anticancer genes directly to a tumor site, according to four presentations of preclinical data at the American Association for Cancer Research (AACR) annual meeting.

CHICAGO--Despite an overall trend toward breast conservation, many breast cancer authorities believe that ductal carcinoma in situ (DCIS) too often is treated by mastectomy, and that axillary dissection and irradiation frequently are performed unnecessarily.

WASHINGTON--The American Cancer Society (ACS) has initiated a new, long-term advocacy program aimed at enhancing its influence on federal and state government actions that affect efforts to eliminate cancer.

SAN DIEGO--So little is known about cell cycling that a new study on a possible mechanism for why cells fail to exit the cell cycle was termed the "most exciting presentation" of the American Association for Cancer Research's 88th annual meeting. Stephen H. Friend, MD, of the Fred Hutchinson Cancer Research Center, made the comment at a press briefing held at the meeting.

KANSAS CITY, Mo--Hoechst Marion Roussel is offering research grants totaling nearly $500,000 to fund health economics and outcomes studies through its 1997 ACCORD (A Company-wide Commitment to Outcomes Research and Development) program.

ASCO--As the country awaits a Supreme Court decision on the constitutionality of state laws forbidding physician-assisted suicide, two physicians presented both sides of the debate at an ASCO session on end-of-life issues.

WASHINGTON-- The federal government should revise its system for funding the training of physicians, to help cut costs and adapt to ongoing changes in health care delivery, says a report from the Institute of Medicine (IOM) at the National Academy of Sciences.

Drs. Buatti and Marcus concisely review the clinical presentation, diagnosis, and current management of pituitary adenomas. It would be difficult, if not impossible, for a brief review article to cover in depth all of the areas of controversy for such a broad subject. Consequently, several supplementary comments are in order.

Johnson and Goldberg provide a comprehensive review of the management of the Pancoast tumor, a bronchogenic carcinoma located in the superior pulmonary sulcus. Due to this specific location, Pancoast tumors can invade nerves, blood vessels, and musculoskeletal structures located at the level of the thoracic inlet. Such invasion can produce a wide range of clinical signs and symptoms, recognized as the Pancoast syndrome.