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A new drug-releasing device is effective in treating cytomegalovirus (CMV) retinitis, a sight-threatening disease that affects one out of four people with AIDS, according to results of a National

SAN DIEGO--Genta Jago, a joint venture between Genta Incorporated and Jagotec AG (Hergiswil, Switzerland), has filed an Investigational New Drug application with the FDA for a controlled-release formulation of zidovudine (AZT), marketed

SAN DIEGO--Genta Incorporated's antisense oligonucleotide targeted against the BCL-2 gene has proved effective against drug-resistant cancers in certain animal models of follicular lymphoma and colon cancer, the company said.

PARIS, France--Although the role of chemotherapy in the management of osteosarcoma was once controversial, a plethora of clinical studies now leave no doubt that chemotherapy dramatically brightens the outlook for patients with this disease.

Doctors soon may be armed with a new technology that allows them to bombard tumors more accurately--and safely--with larger doses of radiation, thanks to research conducted at the University

NEW YORK--Ten women, some of them in wigs, some without eyebrows or eyelashes, sat around a conference table spread with make-up. They were at a free "Improve Your Appearance" clinic at Cancer Care, Inc., where a cosmetician was demonstrating how make-up can improve the special beauty problems that come with chemotherapy.

WASHINGTON--President Clinton proposed an FY 1996 budget of $1.994 billion for the National Cancer Institute. This marks an increase of $78 million over FY 1995. The proposed 1996 appropriation for the National Institutes of Health is $11.793 billion, a 4% increase over the current year.

ALBUQUERQUE--Oncologists and pharmacists at the University of New Mexico initially turned to reduced-dose ondansetron (Zofran) for their pediatric leukemia patients for sheer expediency--most of the children were receiving their

WASHINGTON--William Paul, MD, director of the NIH Office of AIDS Research, has announced that AIDS funding will begin to shift away from clinical research toward investigator-initiated laboratory research. He said that continuation of past policies will result in only "slow, fitful progress."

NEW YORK--An international foundation headquartered in New York City hopes to trigger a national debate about death and dying in the United States. The Project on Death in America will be funded by the Open Society Institute, one of the Soros Foundations.

WASHINGTON--Since the first case of AIDS appeared in the United States in 1981, 60,000 women have been diagnosed with the disease, 14,000 of them (25% of the total number of women) in 1994 alone. HIV in women is increasing at the rate of 17% a year, and one in four new cases in 1994 occurred in women under the age of 20.

PRINCETON, NJ--Direct intratumor radioimmunotherapy (RAIT), with multiple courses delivered via indwelling or removable catheters, resulted in prolonged survival in patients with malignant glioma. Observations in newly diagnosed

ROCKVILLE, Md--In February, as part of an FDA pilot program, representatives of consumer groups sat at the table during an Oncologic Drugs Advisory Committee (ODAC) meeting. The ad hoc representatives from the Treatment Action Group, a New York organization representing people with AIDS, and the National Breast Cancer Coalition participated in the discussions of New Drug Applications but did not have a vote.

CHICAGO--A pair of large-scale clinical investigations reported at the annual meeting of the Radiological Society of North America is renewing the controversy over the need to perform mammography in young women.

WASHINGTON--According to the National Center for Health Statistics (NCHS), cancer now rivals or surpasses heart disease as the leading cause of death in several European countries and parts of Asia and Latin America. The new report is the most comprehensive look at international death rates ever undertaken by the NCHS. It compares age-adjusted death rates from 41 industrialized countries from 1955 through 1991.

The first volume of Cancer Therapy in the Twenty-First Century provides background information on some of the molecular and immunologic approaches that are becoming increasingly important in the diagnosis and management of cancer

STANFORD, Calif--A new single-cell biological sensor system may someday allow rapid screening of cancer agents for biofunctional activity (see illustration on page 1). The test could be used, for example, to identify compounds that bind to or block receptors for biomolecules such as growth factors or other cytokines, or to highlight potentially harmful metabolites.

WHIPPANY, NJ--Two new forms of Dilaudid (hydromorphone HCL)-- Dilaudid 8 mg tablets and Dilaudid-5 Oral Liquid--are now available from Knoll Pharmaceutical Company.

MILAN, Italy--Opioids are not usually the cause of organic brain syndromes (most often delirium and hallucinations) in patients with chronic cancer pain, when other common medical conditions that develop in advanced cancer are considered,

WASHINGTON--The National Institutes of Health, University of Utah, and Myriad Genetics, Inc. have resolved issues involving patenting of the BRCA1 breast cancer gene by agreeing that scientists from all three institutions should be named as joint inventors in current patent applications. The agreement also ensures that exclusive, worldwide commercial rights are retained by Myriad and its licensees, Eli Lilly and Company and Hybritech Incorporated.

SEATTLE--Receptagen Ltd. has begun formal clinical development of its first "growth blocker" drug, based on promising laboratory studies. The agent, a monoclonal antibody that blocks the B12 carrier protein trans-cobalamin II, triggered apoptosis in cancer cells by depleting vitamin B12, an essential enzyme co-factor for cell proliferation, said Receptagen president A. Charles Morgan Jr., PhD.

PARIS, France--A treatment that even modestly improves survival may be important, but most cancer trials are too small to detect such differences, Professor Richard Peto, of Oxford's ICRF Clinical Trial Service Unit, said at the Fifth International

TARRYTOWN, NY--America's major medical research institutions are failing to conduct the nutritional research needed to make a major public health impact on cancer and other diseases, says Peter Greenwald, MD, director of the division of cancer prevention and control at the National Cancer Institute.

PARIS, France--Cancer vaccines are now coming into their own, in advanced as well as early disease, Malcolm S. Mitchell, MD, said at the Fifth International Congress on Anti-Cancer Chemotherapy. Although vaccines have, to date, been most

RESEARCH TRIANGLE PARK, NC--Zofran Tablets (ondansetron), from Cerenex Pharmaceuticals, Division of Glaxo Inc., has received FDA approval for a new indication--the prevention of radiation-induced nausea and vomiting. The oral agent, a 5-HT3 antagonist, is currently marketed for prevention of emesis in cancer patients receiving moderately emetogenic chemotherapy.

ROCKVILLE, Md--After hours of heated debate, the FDA's Oncologic Drugs Advisory Committee (ODAC) decided there was sufficient evidence of efficacy to recommend approval of DOX-SL (pegylated liposomal doxorubicin) for the treatment of AIDS-related Kaposi's sarcoma (KS) in patients who have failed first-line treatment or who cannot tolerate other treatment. The potential benefits of the drug generally outweigh the risks, the committee said.

BETHESDA, Md--Whaijen Soo, MD, vice president for virology, Hoffmann-La Roche, told the National Task Force on AIDS Drug Development that the company's protease inhibitor, saquinavir (Invirase), is now ready for phase III trials

BETHESDA, Md--Intermittent infusions of interleukin-2 (IL-2, aldesleukin) have led to significant increases in CD4+ T cell counts in HIV-infected patients with early disease, a study from the National Institute of Allergy and Infectious Diseases (NIAID) has found.

A look back at the pre-antibiotic era may uncover ways to deal with immunosuppression and drug resistance in today's patients, Dr. Matthew Scharff said at a recent talk sponsored by the Irvington Institute.

ROCKVILLE, Md--Bruce Chabner, MD, director of the NCI Division of Cancer Treatment, said that over the past decade, NCI's drug discovery and development programs have produced seven new drugs currently being used to treat cancer and AIDS. The program cost about $1.4 billion: $200 million for every New Drug Application filed.