Cetuximab plus chemo boosts surgery in advanced colon ca

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Oncology NEWS InternationalOncology NEWS International Vol 18 No 12
Volume 18
Issue 12

Adding cetuximab (Erbitux) to neoadjuvant chemotherapy shrank tumors enough to increase the success of curative surgery in colon cancer patients with inoperable metastatic liver lesions, according to the CELIM trial conducted in Germany and Austria.

Adding cetuximab (Erbitux) to neoadjuvant chemotherapy shrank tumors enough to increase the success of curative surgery in colon cancer patients with inoperable metastatic liver lesions, according to the CELIM trial conducted in Germany and Austria.

Patients were randomized to cetuximab treatment with FOLFOX6 or with FOLFIRI. Treatment with cetuximab resulted in high tumor response rates and a 28% increase in the proportion of tumors that were amenable to surgery. Ultimately, surgery was achieved in 34% of the patients. Because of cetuximab treatment, 60% of tumors were deemed resectable vs 32% at the start of the study (Lancet Oncology online, November 24, 2009).

Articles in this issue
Cetuximab plus chemo boosts surgery in advanced colon ca
OB/GYN revises suggested age for cervical ca screening
Brain tumor gene mapping project launches in Seattle
PET timing guides radiation RX in lung ca
Experts take umbrage with federal panel change to age for mammo screening
Radiosurgery gains role for noncancer applications
New radiotracer shows early treatment response for patients with lung cancer
Addition of rituximab improves OS in chronic lymphocytic leukemia
Micromet scores multiple development deals
New agents for lymphoma take center stage
Vaccines plus screening could end cervical ca
Post-treatment pain remains clinically significant in breast cancer patients
Oncology dodges CMS worst case scenario
RCC adverse effects and symptoms: Kidney cancer specialists must meet new challenges
Classic phase II trials: Unable to meet the challenges in oncology, or an integral aspect of drug development?

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