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Opinion|Videos|January 16, 2026

Debate Topic 2: Defining 1L therapy

Author(s)Saulius Girnius, MD, Jamie Koprivnikar, MD, Aditi Shastri, MBBS

Experts debate the efficacy of luspatercept versus erythropoietin in treating low-risk MDS, emphasizing individualized patient care and emerging therapies.

Episodes in this series

EP. 1 Introduction and Phase 3 COMMANDS Trial

EP. 1 Introduction and Phase 3 COMMANDS Trial

EP. 2 Clinical Implications of COMMANDS Trial

EP. 2 Clinical Implications of COMMANDS Trial

EP. 3 RWO 1L lupatercept vs 2L ESA

EP. 3 RWO 1L lupatercept vs 2L ESA

EP. 4 Insights into RWO 1L lupatercept vs 2L ESA

EP. 4 Insights into RWO 1L lupatercept vs 2L ESA

EP. 5 RWO Hb Assessment in 1L

EP. 5 RWO Hb Assessment in 1L

EP. 6 IMERGE Trial – ASH 2025 Updates

EP. 6 IMERGE Trial – ASH 2025 Updates

EP. 7 Debate Topic 1: Treatment initiation

EP. 7 Debate Topic 1: Treatment initiation

EP. 8 Debate Topic 2: Defining 1L therapy

EP. 8 Debate Topic 2: Defining 1L therapy

EP. 9 Debate Topic 3: Benefits of Completing Lupatercept

EP. 9 Debate Topic 3: Benefits of Completing Lupatercept

EP. 10 Clinical Scenario: A 77-year-old male with newly diagnosed LR-MDS

EP. 10 Clinical Scenario: A 77-year-old male with newly diagnosed LR-MDS

EP. 11 Clinical Scenario: A 70-year-old female with LR-MDS

EP. 11 Clinical Scenario: A 70-year-old female with LR-MDS

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