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Opinion|Videos|January 23, 2026

Debate Topic 3: Benefits of Completing Lupatercept

Author(s)Saulius Girnius, MD, Jamie Koprivnikar, MD, Aditi Shastri, MBBS

Experts debate the optimal dose escalation strategy for Luspatercept in treating low-risk MDS, emphasizing patient-centric approaches and long-term outcomes.

Episodes in this series

EP. 1 Introduction and Phase 3 COMMANDS Trial

EP. 1 Introduction and Phase 3 COMMANDS Trial

EP. 2 Clinical Implications of COMMANDS Trial

EP. 2 Clinical Implications of COMMANDS Trial

EP. 3 RWO 1L lupatercept vs 2L ESA

EP. 3 RWO 1L lupatercept vs 2L ESA

EP. 4 Insights into RWO 1L lupatercept vs 2L ESA

EP. 4 Insights into RWO 1L lupatercept vs 2L ESA

EP. 5 RWO Hb Assessment in 1L

EP. 5 RWO Hb Assessment in 1L

EP. 6 IMERGE Trial – ASH 2025 Updates

EP. 6 IMERGE Trial – ASH 2025 Updates

EP. 7 Debate Topic 1: Treatment initiation

EP. 7 Debate Topic 1: Treatment initiation

EP. 8 Debate Topic 2: Defining 1L therapy

EP. 8 Debate Topic 2: Defining 1L therapy

EP. 9 Debate Topic 3: Benefits of Completing Lupatercept

EP. 9 Debate Topic 3: Benefits of Completing Lupatercept

EP. 10 Clinical Scenario: A 77-year-old male with newly diagnosed LR-MDS

EP. 10 Clinical Scenario: A 77-year-old male with newly diagnosed LR-MDS

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Stay up to date on recent advances in the multidisciplinary approach to cancer.

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Navigating the Adverse Event Landscape in HER2+ GEA Therapy

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PER Resource Center: Integrating Novel Approaches in TNBC – New Avenues for TROP2-Targeting ADCs and Beyond – Nursing

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21st Annual New York Lung Cancers Symposium®

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Medical Crossfire® in Adjunctive Testing: Charting a New Course in Prostate Cancer Risk Assessment

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The Rise of Novel HER2-Targeting Therapies in GEA: Mechanisms and Clinical Data

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Revolutionizing TGCT Care with Multidisciplinary Perspectives and Cutting-Edge Targeted Therapies

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SimulatEd™: A Roadmap to Personalized Care Plans and Shared Decision-Making in Low-Grade Serous Ovarian Cancer

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