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Opinion|Videos|February 28, 2025

Frontline Treatment and Molecular Testing in Upper GI Cancer: Precision-Guided Therapy

Author(s)David Zhen, MD, Nataliya V. Uboha, MD, PhD, Samuel Cytryn, MD

Experts discuss frontline treatment options for advanced upper gastric adenocarcinoma, molecular testing methods, challenges encountered, and how test results influence the choice of systemic therapy for patients.

Episodes in this series

EP. 1 HER2- Upper GI Cancer

EP. 1 HER2- Upper GI Cancer

EP. 2 Frontline Treatment and Molecular Testing in Upper GI Cancer: Precision-Guided Therapy

EP. 2 Frontline Treatment and Molecular Testing in Upper GI Cancer: Precision-Guided Therapy

EP. 3 Reflex Testing in Upper GI Cancer: Optimizing Molecular Insights for Timely Treatment

EP. 3 Reflex Testing in Upper GI Cancer: Optimizing Molecular Insights for Timely Treatment

EP. 4 The Role of Biomarkers for Immunotherapy Selection in Upper GI Cancer

EP. 4 The Role of Biomarkers for Immunotherapy Selection in Upper GI Cancer

EP. 5 Reassessing Biomarkers: Guiding Second-Line Therapy in Upper GI Cancer

EP. 5 Reassessing Biomarkers: Guiding Second-Line Therapy in Upper GI Cancer

EP. 6 Navigating Prognosis and Treatment Goals in Upper GI Cancer: A Patient- and Family-Centered Approach

EP. 6 Navigating Prognosis and Treatment Goals in Upper GI Cancer: A Patient- and Family-Centered Approach

EP. 7 Megan’s Journey With HER2+ Upper GI Cancer

EP. 7 Megan’s Journey With HER2+ Upper GI Cancer

EP. 8 Understanding PD-L1 CPS: Impact on Treatment Decisions in HER2+ Gastric Cancer

EP. 8 Understanding PD-L1 CPS: Impact on Treatment Decisions in HER2+ Gastric Cancer

EP. 9 ADCs in HER2+ Gastric Cancer

EP. 9 ADCs in HER2+ Gastric Cancer

EP. 10 Biomarkers and Clinical Features Guiding HER2-Directed Therapy in Upper GI Cancer

EP. 10 Biomarkers and Clinical Features Guiding HER2-Directed Therapy in Upper GI Cancer

EP. 11 Considerations for Combinations Beyond Progression in Upper GI Cancer

EP. 11 Considerations for Combinations Beyond Progression in Upper GI Cancer

EP. 12 Exploring Next-Line Options in HER2- MSS Gastric Cancer

EP. 12 Exploring Next-Line Options in HER2- MSS Gastric Cancer

Video content above is prompted by the following:

Before we dive in, could you briefly provide an overview of frontline treatment options for patients with advanced upper gastric adenocarcinoma?
When do you perform molecular testing, and what choice of testing method do you use?
What are some challenges that you have encountered?
How do the results influence the choice of systemic therapy in this patient?

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