Opinion|Videos|May 31, 2024
Insights from CARTITUDE-4 and KarMMa-3 in R/R MM
Experts on multiple myeloma provide their impressions of the CARTITUDE-4 and KarMMa-3 studies, which led to the approval of cilta-cel and ide-cel in earlier lines of treatment for patients with relapsed/refractory disease.
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Video content above is prompted by the following questions:
- Briefly review the CARTITUDE-4 trial that led to cilta-cel’s approval in earlier lines of treatment for relapsed/refractory multiple myeloma (R/R MM).
- Please comment on the patient population – intention-to-treat vs patients treated.
- What was the rationale for the difference? How does it affect your interpretation of the data?
- How did the safety outcomes compare with other CARTITUDE trials?
- Please share your real-world experience.
- Please review data from KarMMa-3, which led to ide-cel’s approval in earlier lines of therapy for R/R MM.
- What are thoughts on the efficacy and safety outcomes?
- Please share your real-world experience.
- How do these approvals impact the current and future treatment landscape of R/R MM?
- How might you choose one over the other?
- How does it address an unmet need?
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Related to this article
In a phase 2 trial, CD38-targeted immune-PET detected active multiple myeloma in some patients with no signs of disease on standard fluorodeoxyglucose PET/CT.
“If it is successful, you should be able to access this combination wherever you are,” said Natalie S. Callander, MD, of the UW Carbone Cancer Center.
Data from the phase 3 CERVINO trial support the application for etentamig as a treatment for adults with relapsed or refractory multiple myeloma.
The MagnetisMM-32 trial may support elranatamab as an important option for those whose disease has progressed following anti-CD38 therapy and lenalidomide.
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