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Opinion|Videos|May 31, 2024

Insights from CARTITUDE-4 and KarMMa-3 in R/R MM

Author(s)Saad Z. Usmani, MD, MBA, FACP, Rahul Banerjee, MD, FACP, Doris Hansen, MD

Experts on multiple myeloma provide their impressions of the CARTITUDE-4 and KarMMa-3 studies, which led to the approval of cilta-cel and ide-cel in earlier lines of treatment for patients with relapsed/refractory disease.

Episodes in this series

A panel of 4 experts on multiple myeloma

EP. 1 The Rationale for CAR T-Cell Therapy in Relapsed/Refractory Multiple Myeloma

A panel of 4 experts on multiple myeloma

EP. 2 The Impact of CAR T-Cell Therapy on Relapsed/Refractory MM Treatment

A panel of 4 experts on multiple myeloma

EP. 3 How CAR T-Cell Therapy Impacts Relapsed/Refractory MM Treatment

A panel of 4 experts on multiple myeloma

EP. 4 Key Takeaways from the CARTITUDE-1 and KarMMa Studies

A panel of 4 experts on multiple myeloma

EP. 5 CAR T-Cell Therapy in R/R MM: Treatment Selection, Safety, and Future Perspectives

A panel of 4 experts on multiple myeloma

EP. 6 Insights from CARTITUDE-4 and KarMMa-3 in R/R MM

A panel of 4 experts on multiple myeloma

EP. 7 Future Perspectives on CAR T-Cell Therapy in Relapsed/Refractory MM

Video content above is prompted by the following questions:

Briefly review the CARTITUDE-4 trial that led to cilta-cel’s approval in earlier lines of treatment for relapsed/refractory multiple myeloma (R/R MM).
- Please comment on the patient population – intention-to-treat vs patients treated.
- What was the rationale for the difference? How does it affect your interpretation of the data?
- How did the safety outcomes compare with other CARTITUDE trials?
- Please share your real-world experience.
Please review data from KarMMa-3, which led to ide-cel’s approval in earlier lines of therapy for R/R MM.
- What are thoughts on the efficacy and safety outcomes?
- Please share your real-world experience.
How do these approvals impact the current and future treatment landscape of R/R MM?
- How might you choose one over the other?
- How does it address an unmet need?

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