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Opinion|Videos|September 10, 2024

Managing toxicities of BCMA_targeting Bispecfics

Author(s)Larysa Sanchez, MD, Samantha Shenoy, NP, MSN

Experts explore additional toxicities observed with B-cell maturation antigen–targeting bispecifics, such as infections, neurotoxicity, and hematological issues, and discuss how these are managed in practice.

Episodes in this series

$EP. 1 Overview of Relapsed/Refractory Multiple Myeloma: Diagnosis, Treatment Options, Unmeet Needs$

EP. 1 Overview of Relapsed/Refractory Multiple Myeloma: Diagnosis, Treatment Options, Unmeet Needs

EP. 2 MonumenTAL-1: Long Term Follow up Efficacy

EP. 2 MonumenTAL-1: Long Term Follow up Efficacy

EP. 3 MonumenTAL-1: Safety and AEs

EP. 3 MonumenTAL-1: Safety and AEs

EP. 4 Managing GPRC5D Therapy: Unique AE Challenges and Patient Preparation

EP. 4 Managing GPRC5D Therapy: Unique AE Challenges and Patient Preparation

EP. 5 Administering GPRC5D therapy: Dosing and Monitoring for CRS & ICANS

EP. 5 Administering GPRC5D therapy: Dosing and Monitoring for CRS & ICANS

EP. 6 Managing toxicities of BCMA_targeting Bispecfics

EP. 6 Managing toxicities of BCMA_targeting Bispecfics

EP. 7 Management of Oral Toxcities associated with GPRC5D Bispecifics Nail

EP. 7 Management of Oral Toxcities associated with GPRC5D Bispecifics Nail

EP. 8 Management of Skin and Nail AEs: Advice to Patients and Caregivers

EP. 8 Management of Skin and Nail AEs: Advice to Patients and Caregivers

EP. 9 Prophylactic Strategies and Advice for Managing AEs in Bispecific Therapies

EP. 9 Prophylactic Strategies and Advice for Managing AEs in Bispecific Therapies

EP. 10 Unmet Needs and Future Perspectives on the treatment of R/R MM

EP. 10 Unmet Needs and Future Perspectives on the treatment of R/R MM

Video content above is prompted by the following:

What are some other toxicities observed with B-cell maturation antigen–targeting bispecifics? How are they managed in your practice?

Infections, neurotoxicity, hematological toxicities

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Vinay K. Puduvalli, MD; Manmeet Ahluwalia, MD, MBA; Stephen J. Bagley, MD, MSCE; Angela Waanders, MD, MPH, MS

PER Tumor Board®: Applying Recent Advances to Transform the Treatment Paradigm in SCLC—Expert Perspectives on New Approvals and Emerging Strategies

PER Tumor Board®: Applying Recent Advances to Transform the Treatment Paradigm in SCLC—Expert Perspectives on New Approvals and Emerging Strategies

Jonathan W. Goldman, MD; Percy Lee, MD, FASTRO; Erminia Massarelli, MD, PhD, MS; Misty D. Shields, MD, PhD

Evolving Treatment Strategies in Pancreatic Cancer: Current Standards, Emerging Targets, and the Role of Molecular Testing

Evolving Treatment Strategies in Pancreatic Cancer: Current Standards, Emerging Targets, and the Role of Molecular Testing

Eileen M. O’Reilly, MD; E. Gabriela Chiorean, MD, FASCO; Michael J. Pishvaian, MD, PhD; Brian Wolpin, MD, MPH

Medical Crossfire®: Integrating Next-Generation Endocrine Targeting Therapies to Improve Outcomes for Patients With HR+/HER2- Breast Cancer

Medical Crossfire®: Integrating Next-Generation Endocrine Targeting Therapies to Improve Outcomes for Patients With HR+/HER2- Breast Cancer

William J. Gradishar, MD, FASCO, FACP; Laura Huppert, MD; Yuan Yuan, MD, PhD

Breaking Down the Rationale for Targeting TROP2 in TNBC

Breaking Down the Rationale for Targeting TROP2 in TNBC

Filipa Lynce, MD; Rita Nanda, MD

Cross-Disease Integration of Immunotherapy Innovations

Cross-Disease Integration of Immunotherapy Innovations

Ghassan Abou-Alfa, MD, MBA; Laura Williams Goff, MD, MSCI, MMHC, FASCO; Arndt Vogel, MD, PhD

PER Resource Center: Integrating Novel Approaches in TNBC – New Avenues for TROP2-Targeting ADCs and Beyond – Nursing

PER Resource Center: Integrating Novel Approaches in TNBC – New Avenues for TROP2-Targeting ADCs and Beyond – Nursing

Aditya Bardia, MD, MPH, FASCO; Erika P. Hamilton, MD; Virginia Kaklamani, MD, DSc; Filipa Lynce, MD; Rita Nanda, MD; Tiffany A. Traina, MD, FASCO

Medical Crossfire® in Adjunctive Testing: Charting a New Course in Prostate Cancer Risk Assessment

Medical Crossfire® in Adjunctive Testing: Charting a New Course in Prostate Cancer Risk Assessment

Jason Hafron, MD; Aaron D. Berger, MD; Arpeet Shah, MD

Community Practice Connections™: Enhancing Melanoma Outcomes With Intratumoral Oncolytic Immunotherapy–Strategies for the Multidisciplinary Team

Community Practice Connections™: Enhancing Melanoma Outcomes With Intratumoral Oncolytic Immunotherapy–Strategies for the Multidisciplinary Team

Yana G. Najjar, MD; Sapna Patel, MD

Community Practice Connections™: Optimizing SCLC Treatment Strategies and Managing Adverse Events Across Disease Stages

Community Practice Connections™: Optimizing SCLC Treatment Strategies and Managing Adverse Events Across Disease Stages

Erminia Massarelli, MD, PhD, MS; Misty D. Shields, MD, PhD

Navigating the Adverse Event Landscape in HER2+ GEA Therapy

Navigating the Adverse Event Landscape in HER2+ GEA Therapy

Rahul Gosain, MD, MBA; Rohit Gosain, MD; Geoffery Ku, MD; Shruti Patel, MD

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