Phase I Trial of NPI-0052 Begins

Publication
Article
Oncology NEWS InternationalOncology NEWS International Vol 15 No 6
Volume 15
Issue 6

Nereus Pharmaceuticals, Inc. has initiated a phase I trial of its novel, small molecule proteasome inhibitor, NPI-0052, in patients with solid tumors and lymphomas. The trial will enroll approximately 50 patients at two sites, M.D. Anderson Cancer Center and Memorial Sloan-Kettering Cancer Center. NPI-0052 was discovered during the fermentation of Salinispora sp, a new class of Gram-positive marine bacteria, Nereus said in a press release.

SAN DIEGO, Calif—Nereus Pharmaceuticals, Inc. has initiated a phase I trial of its novel, small molecule proteasome inhibitor, NPI-0052, in patients with solid tumors and lymphomas. The trial will enroll approximately 50 patients at two sites, M.D. Anderson Cancer Center and Memorial Sloan-Kettering Cancer Center. NPI-0052 was discovered during the fermentation of Salinispora sp, a new class of Gram-positive marine bacteria, Nereus said in a press release.

Articles in this issue
Triple-Negative Cancers More Common in Young Black Pts
Artists Turn Flowers & Curves Into 'Forms' and 'Figures'
Study to Examine Outcomes Disparities in Pediatric ALL
Thalidomide Has 'Changed the Paradigm' in Myeloma Rx
CA4P Gets Orphan Drug Status
Testicular Ca Survivors at Increased Risk for CV Events
A Novel Brings a Cancer Research Laboratory to Life
NCCN Reveals New Venous Thromboembolism Guideline
Lapatinib New Option for Metastatic HER2+ Breast Ca
FDA Approves Dacogen for Treating All MDS Subtypes
Noninvasive Ablation Relieves Chronic Chest Wall Pain
GVAX Receives Fast-Track Status
Medicare CAP Vendor Selected
Selective IGF-1R Inhibitor Blocks Colon Cancer Growth
US Cancer Mortality Drops
Recent Videos
Analysis of 2 phase 1 trials compared gut biome diversity between standard of care with or without CBM588 in patients with metastatic renal cell carcinoma.
A panel of 4 experts on multiple myeloma
A panel of 4 experts on multiple myeloma
4 KOLs are featured in this panel.
4 KOLs are featured in this panel.
Isabel Preeshagul, DO, MBS, with the Oncology Brothers presenting slides
Isabel Preeshagul, DO, MBS, with the Oncology Brothers presenting slides
Isabel Preeshagul, DO, MBS, with the Oncology Brothers presenting slides
Isabel Preeshagul, DO, MBS, with the Oncology Brothers presenting slides
2 KOLs are featured in this series
Related Content
The novel drug showed promise in helping to decrease chemotherapy-induced peripheral neuropathy for those who had received prior chemotherapy.

SON-080 May Decrease Chemotherapy-Induced Peripheral Neuropathy

Ariana Pelosci
July 26th 2024
Article

The novel drug showed promise in helping to decrease chemotherapy-induced peripheral neuropathy for those who had received prior chemotherapy.

Experts discuss findings related to liquid biopsy profiling, later-line immunotherapy, and CDK4/6 inhibitor efficacy presented at the 2024 KCRS meeting.

Exploring New Possibilities in Kidney Cancer Detection and Therapy

Karl Semaan, MD, MSc ;Neil J. Shah, MBBS;Bradley McGregor, MD
July 22nd 2024
Podcast

Experts discuss findings related to liquid biopsy profiling, later-line immunotherapy, and CDK4/6 inhibitor efficacy presented at the 2024 KCRS meeting.

The FDA has set a Prescription Drug User Fee Act date of December 28, 2024, for cosibelimab in advanced or metastatic cutaneous squamous cell carcinoma.

FDA Accepts Resubmitted BLA for Cosibelimab in Advanced Skin Cancer

Russ Conroy
July 26th 2024
Article

The FDA has set a Prescription Drug User Fee Act date of December 28, 2024, for cosibelimab in advanced or metastatic cutaneous squamous cell carcinoma.

Leaders from the lymphoma space highlight the importance of mentorship in establishing their careers and impart advice to women looking to advance theirs.

Overcoming Physical and Social Barriers in the Lymphoma Field

Julie M. Vose, MD, MBA;Avyakta Kallam, MD
July 15th 2024
Podcast

Leaders from the lymphoma space highlight the importance of mentorship in establishing their careers and impart advice to women looking to advance theirs.

Members agreed that perioperative regimen NSCLC trial designs should clarify the contribution of treatment during adjuvant and neoadjuvant therapy.

ODAC Votes in Favor of New Perioperative NSCLC Trial Design Proposals

Russ Conroy
July 25th 2024
Article

Members agreed that perioperative regimen NSCLC trial designs should clarify the contribution of treatment during adjuvant and neoadjuvant therapy.

Multiple confirmed responses in a phase 2 trial support the FDA designation for the experimental therapy in squamous cell carcinoma of the head and neck.

Ozuriftamab Vedotin Gains FDA Fast Track Designation for Recurrent SCCHN

Roman Fabbricatore
July 25th 2024
Article

Multiple confirmed responses in a phase 2 trial support the FDA designation for the experimental therapy in squamous cell carcinoma of the head and neck.