Robert J. Motzer, MD, on Research Areas of Focus in Renal Cell Carcinoma

Video

The medical oncologist at Memorial Sloan Kettering Cancer Center discussed areas of research in renal cell carcinoma that he thinks should be further explored.

In an interview with CancerNetwork®, Robert J. Motzer, MD, a medical oncologist at Memorial Sloan Kettering Cancer Center, highlighted areas of research within renal cell carcinoma (RCC) which he believes should be studied further.

Transcription:

I think we’ve made tremendous headway with [immuno-oncology] combinations. I’m hoping that some of the drugs with novel mechanism of actions like [belzutifan; MK-6482], will bear fruit and advance our therapeutic options. And I think the other area that really needs to be explored is a better look and a deep dive into the underlying tumor biology and why some patients respond to 1 medication and some respond to another. Are there different targets that we can identify within the tumors? That’'\s an area now that really needs to be explored.

Newsletter

Stay up to date on recent advances in the multidisciplinary approach to cancer.

Recent Videos
“If you have a [patient in the] fourth or fifth line, [JNJ-5322] could be a valid drug of choice,” said Rakesh Popat, BSc, MBBS, MRCP, FRCPath, PhD.
Earlier treatment with daratumumab may be better tolerated for patients with pretreated MRD-negative multiple myeloma.
The trispecific antibody JNJ-5322 demonstrated superior efficacy vs approved agents in multiple myeloma in results shared at the 2025 EHA Congress.
Despite CD19 CAR T-cell therapy exhibiting efficacy in patients with relapsed/refractory large B-cell lymphoma, less than half achieve long-term remission.
Current findings from the phase 1/2 CaDAnCe-101 trial show no predictive factors of improved responses with BGB-16673 in patients with CLL or SLL.
The phase 3 NIVOSTOP trial evaluated an anti–PD-1 immunotherapy, nivolumab, in a patient population similar in the KEYNOTE-689 trial.
Related Content