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Opinion|Videos|May 4, 2026

Safety Profile and Treatment Emergent Adverse Events

Author(s)Martin H. Voss, MD, Matthew T. Campbell, MD, MS

Episodes in this series

EP. 1 Framing LITESPARK-011 in a Changing RCC Landscape

EP. 1 Framing LITESPARK-011 in a Changing RCC Landscape

EP. 2 How Rapid Therapeutic Evolution Has Complicated RCC Sequencing

EP. 2 How Rapid Therapeutic Evolution Has Complicated RCC Sequencing

EP. 3 Selecting First-Line Therapy Based on Disease Biology and Risk

EP. 3 Selecting First-Line Therapy Based on Disease Biology and Risk

EP. 4 Treatment Intensity Tradeoffs and the Role of TKI Strategy

EP. 4 Treatment Intensity Tradeoffs and the Role of TKI Strategy

EP. 5 Targeting HIF-2 Alpha as a Novel Therapeutic Strategy

EP. 5 Targeting HIF-2 Alpha as a Novel Therapeutic Strategy

EP. 6 LITESPARK-011 Trial Design and Endpoints

EP. 6 LITESPARK-011 Trial Design and Endpoints

EP. 7 Interpreting Study Population and Applicability to Practice

EP. 7 Interpreting Study Population and Applicability to Practice

EP. 8 Evaluating Progression Free Survival and Response Outcomes

EP. 8 Evaluating Progression Free Survival and Response Outcomes

EP. 9 Understanding Treatment Effect Timing

EP. 9 Understanding Treatment Effect Timing

EP. 10 Subgroup Analyses and Signals Across Risk Categories

EP. 10 Subgroup Analyses and Signals Across Risk Categories

EP. 11 Interpreting Duration of Response in the Second Line Setting

EP. 11 Interpreting Duration of Response in the Second Line Setting

EP. 12 Safety Profile and Treatment Emergent Adverse Events

This segment reviews the safety and tolerability of belzutifan plus lenvatinib. The combination was associated with a high incidence of treatment-emergent adverse events, including grade 3 or higher toxicities, consistent with the known profiles of the individual agents. The discussion highlights the importance of managing side effects such as hypertension, fatigue, and laboratory abnormalities through dose adjustments and supportive care. The speakers emphasize that while toxicity is expected with combination therapy, careful monitoring can help patients remain on treatment. This segment underscores the need to balance efficacy with tolerability when selecting therapy for patients with advanced RCC and highlights the practical considerations involved in managing combination regimens.

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