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Opinion|Videos|November 22, 2024

T-DXd in HER2-Overexpressing and HER2-Mutated NSCLC: Clinical Trial Data and Insights

Author(s)Rohit Gosain, MD, Rahul Gosain, MD, Benjamin P. Levy, MD

Panelists discuss how the evolving treatment landscape for HER2-overexpressing NSCLC, particularly with the introduction of trastuzumab deruxtecan, influences therapeutic strategies and decision-making based on recent clinical trial data.

Episodes in this series

EP. 1 An Overview of HER2 Alterations in NSCLC and Implications for Treatment

EP. 1 An Overview of HER2 Alterations in NSCLC and Implications for Treatment

EP. 2 Biomarker Testing in NSCLC: Best Practices for Personalized Medicine

EP. 2 Biomarker Testing in NSCLC: Best Practices for Personalized Medicine

EP. 3 T-DXd in HER2-Overexpressing and HER2-Mutated NSCLC: Clinical Trial Data and Insights

EP. 3 T-DXd in HER2-Overexpressing and HER2-Mutated NSCLC: Clinical Trial Data and Insights

EP. 4 ADCs, TKIs, and the Evolving Treatment Landscape in HER2-Altered NSCLC

EP. 4 ADCs, TKIs, and the Evolving Treatment Landscape in HER2-Altered NSCLC

EP. 5 AE Monitoring and Management With Targeted Therapies in NSCLC

EP. 5 AE Monitoring and Management With Targeted Therapies in NSCLC

EP. 6 Thoracic Oncologist Perspectives on a Rapidly Evolving Treatment Landscape

EP. 6 Thoracic Oncologist Perspectives on a Rapidly Evolving Treatment Landscape

EP. 7 Identifying HER2 Mutations for T-DXd Use in NSCLC

EP. 7 Identifying HER2 Mutations for T-DXd Use in NSCLC

(Rahul asks Rohit) Could you provide an overview of the current treatment landscape for HER2-overexpressing NSCLC? What is considered the SOC in various lines of treatment, and how do different therapeutic strategies—such as immunotherapy, chemotherapy, HER2-targeted therapies, and combination approaches—fit into various lines of treatment?
(Rohit asks Levy, please state indication) T-DXd is approved for HER2-positive (IHC 3+) solid tumors after prior systemic therapy and is in the NCCN guidelines for IHC 3+ occult tumors.How has the emergence of HER2-targeted therapies, particularly trastuzumab deruxtecan, reshaped your treatment approach in HER2-overexpressing NSCLC from biomarker interpretation to treatment decision-making across different lines of therapy?
With the advent of targeted therapies and personalized medicine, how has the interpretation of biomarker testing, including IHC scoring and disease drivers, shifted your treatment decision-making?
(Rohit asks Rahul) Can you provide some background on clinical trial data updates with T-DXd in HER2-overexpressing NSCLC?
DESTINY-Lung01: Cohort 1/1A (Smit E. The Lancet. 2024)
DESTINY-Lung03 (Planchard D. WCLC 2024. Abstract OA16.05)
(Rahul asks Levy) Given the data from these trials, how would you incorporate T-DXd into your treatment approach for patients with HER2-overpressing NSCLC?
In which lines of therapy would you consider T-DXd in HER2-overexpressing NSCLC? (Please feel free to comment on your experience using T-DXd in HER2-mutant NSCLC)

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