Opinion|Videos|March 13, 2025
Treatment Sequencing in HER2+ mBC: Real-World Data & Key Considerations in Third-Line Treatment Selection
Experts discuss treatment options for HER2-positive metastatic breast cancer following progression on trastuzumab deruxtecan (T-DXd), weighing real-world data on tucatinib-capecitabine-trastuzumab versus T-DM1, considering factors such as resistance mechanisms, administration preferences, and side effect management.
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Video content above is prompted by the following:
- What are the available treatment options after progression on trastuzumab deruxtecan (Tdxd), and how do real-world data support the use of tucatinib-based regimens or T-DM1?
- How does the choice between tucatinib-capecitabine-trastuzumab (HER2CLIMB regimen) and T-DM1 depend on patient-specific factors such as toxicity, prior treatment exposure, and logistical considerations?
- How do different mechanisms of HER2 inhibition influence treatment sequencing, and does prior exposure to tyrosine kinase inhibitors (TKIs) impact the efficacy of T-DM1?
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