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Opinion|Videos|March 13, 2025

Treatment Sequencing in HER2+ mBC: Real-World Data & Key Considerations in Third-Line Treatment Selection

Experts discuss treatment options for HER2-positive metastatic breast cancer following progression on trastuzumab deruxtecan (T-DXd), weighing real-world data on tucatinib-capecitabine-trastuzumab versus T-DM1, considering factors such as resistance mechanisms, administration preferences, and side effect management.

Episodes in this series

EP. 1 Treatment Selection and Sequencing in Third Line Settings and Beyond

EP. 1 Treatment Selection and Sequencing in Third Line Settings and Beyond

EP. 2 Understanding Janet's Journey: Navigating HER2+ Metastatic Breast Cancer & Treatment Options

EP. 2 Understanding Janet's Journey: Navigating HER2+ Metastatic Breast Cancer & Treatment Options

EP. 3 Exploring Third-Line Options in HER2+ mBC: Janet’s Case & Key Trial Insights from HER2CLIMB and EMILIA

EP. 3 Exploring Third-Line Options in HER2+ mBC: Janet’s Case & Key Trial Insights from HER2CLIMB and EMILIA

EP. 4 Treatment Sequencing in HER2+ mBC: Real-World Data & Key Considerations in Third-Line Treatment Selection

EP. 4 Treatment Sequencing in HER2+ mBC: Real-World Data & Key Considerations in Third-Line Treatment Selection

EP. 5 Managing Oral Treatments and Patient Support Strategies in HER2+ mBC: Multidisciplinary Perspectives

EP. 5 Managing Oral Treatments and Patient Support Strategies in HER2+ mBC: Multidisciplinary Perspectives

EP. 6 Barbara's Story: Navigating HER2+ MBC with Brain Metastases & Tucatinib-Based Treatment in the Second-Line Setting

EP. 6 Barbara's Story: Navigating HER2+ MBC with Brain Metastases & Tucatinib-Based Treatment in the Second-Line Setting

EP. 7 Evolving Treatment Strategies in Early HER2+ Breast Cancer

EP. 7 Evolving Treatment Strategies in Early HER2+ Breast Cancer

EP. 8 Local and Systemic Approaches in Treating Brain Metastases in HER2+ mBC: The Role of Radiation and SRS

EP. 8 Local and Systemic Approaches in Treating Brain Metastases in HER2+ mBC: The Role of Radiation and SRS

EP. 9 Treatment Selection, Sequencing, and Supportive Care for Brain Metastases in HER2+ mBC

EP. 9 Treatment Selection, Sequencing, and Supportive Care for Brain Metastases in HER2+ mBC

Video content above is prompted by the following:

What are the available treatment options after progression on trastuzumab deruxtecan (Tdxd), and how do real-world data support the use of tucatinib-based regimens or T-DM1?
How does the choice between tucatinib-capecitabine-trastuzumab (HER2CLIMB regimen) and T-DM1 depend on patient-specific factors such as toxicity, prior treatment exposure, and logistical considerations?
How do different mechanisms of HER2 inhibition influence treatment sequencing, and does prior exposure to tyrosine kinase inhibitors (TKIs) impact the efficacy of T-DM1?

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