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Opinion|Videos|March 31, 2026

Unmet Needs in Early Relapse Multiple Myeloma

Author(s)Luciano Costa, MD , Muhamed Baljevic, MD, Carol Ann Huff, MD

Episodes in this series

EP. 1 Defining Early Relapse and Treatment Selection in Multiple Myeloma

EP. 1 Defining Early Relapse and Treatment Selection in Multiple Myeloma

EP. 2 Unmet Needs in Early Relapse Multiple Myeloma

EP. 2 Unmet Needs in Early Relapse Multiple Myeloma

In this segment on early relapse multiple myeloma, Luciano Costa invites Muhamed Baljevic to reflect on persistent unmet needs despite advances in frontline and relapsed treatment strategies. Dr. Baljevic highlights that patients who relapse early after modern induction and maintenance therapies often represent a biologically high-risk population, with more aggressive disease features and shorter durations of response to subsequent lines of therapy. He emphasizes that outcomes remain suboptimal for patients who are refractory to key agents such as lenalidomide or anti-CD38 monoclonal antibodies, as these individuals have fewer effective standard options and may experience diminishing benefit with conventional regimens. The discussion also underscores the challenges in sequencing therapies and the need for novel mechanisms of action to improve durability of response. Overall, this segment reinforces that early relapse multiple myeloma continues to represent an area of significant clinical need, particularly for high-risk and treatment-refractory patient subsets.

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