Authors

Minimal Residual Disease–Directed Adjuvant Therapy for Patients With Early-Stage Colon Cancer: CIRCULATE-US

Ibrahim Halil Sahin, MD, and colleagues, explore, the CIRCULATE-US (NRG-GI008; NCT05174169) investigating postoperative ctDNA dynamics in early-stage colon cancer for treatment selection.

40 An AI Digital Twin Compares Favorably to Radiologists for Landmark Identification and Measurement in Early-Stage Breast Cancer: A Retrospective, Multi-Institution Clinical Study

In a retrospective multi-institution study of 267 early-stage breast cancer patients, the TumorSight Viz AI algorithm achieved landmark identification and measurement accuracy comparable to inter-radiologist variability, generating results in an average of 8 minutes per patient.

Unusual Initial Presentation of Hepatocellular Carcinoma as a Clavicular Head Mass

Rohit Gupta, MD, et al review a case study of a 70-year-old man who presented with a head mass, and the final diagnosis was hepatocellular carcinoma.

51 The Race, Staging, and Clinical Correlations With Genetic Mutations Diagnosed in Breast Cancer Patients of Multiethnicity Background

Minimal Residual Disease–Directed Adjuvant Therapy for Patients With Early-Stage Colon Cancer: CIRCULATE-US

Ibrahim Halil Sahin, MD, and colleagues, explore, the CIRCULATE-US (NRG-GI008; NCT05174169) investigating postoperative ctDNA dynamics in early-stage colon cancer for treatment selection.

36 Are Positive Margins in DCIS a True Indication of Inadequate Surgery?

Circulating Tumor DNA as a Predictive Biomarker for Clinical Outcomes With Margetuximab and Pembrolizumab in Pretreated HER2-Positive Gastric/ Gastroesophageal Adenocarcinoma

Daniel V. T. Catenacci, MD, and colleagues present findings from a study of circulating tumor DNA as a predictive biomarker for gastric and gastroesophageal cancer.

09 Radiologists’ and Ultrasound Artificial Intelligence Decision-Support Assessment of Benign and Malignant Cystic Breast Lesions

In 77 biopsy-proven cystic breast lesions, radiologists achieved significantly higher diagnostic accuracy than the KOIOS DS™ AI tool for malignant cystic lesions (92% vs 76% BI-RADS/suspicious classification).

20 On the Upswing: A Retrospective Cohort Study Evaluating Neoadjuvant Chemotherapy Response in Metaplastic Breast Cancer Patients

In 21 patients with metaplastic breast cancer receiving neoadjuvant chemotherapy, 48% achieved pCR—higher than prior estimates—with all pCR patients alive and disease-free at follow-up, suggesting modern regimens including pembrolizumab may improve outcomes in this chemoresistant subtype.

31 E-Strain Elastography as an Adjunct of Breast Ultrasound: Impact on Biopsy Decision-Making

In 161 biopsied breast masses, malignant lesions showed significantly higher E-strain ratios than benign lesions (3.51 vs 1.93), with progressive increases across BI-RADS categories, supporting elastography as an adjunct to biopsy decision-making.

44 Long-Term Oncological Outcomes After Oncoplastic Therapeutic Mammoplasty With Contralateral Symmetrisation for Early Breast Cancer: A Thirteen-Year Single-Centre Cohort Study

Therapeutic mammoplasty with contralateral symmetrization showed low long-term local recurrence in early breast cancer, with failure to complete adjuvant therapy as the strongest modifiable predictor of recurrence.