Breast Cancer

Developed initially for the treatment of malignant melanoma, lymphatic mapping and sentinel lymph node biopsy have recently been introduced into the treatment of early breast cancer. In breast cancer patients, harvested

HOUSTON--More than half of the patients who present to M.D. Anderson Cancer Center’s emergency room have a complaint of dyspnea, Sandra Henke, RN, a thoracic oncology nurse at M.D. Anderson, said at the Center’s 2nd Annual Nursing Conference. "Even when there are other emergency symptoms, breathing difficulties are the most pronounced because they cause the most distress for the patient," Ms. Henke said.

The Center for Breast Care at UT Southwestern Medical Center in Dallas and the Susan G. Komen Breast Cancer Foundation have teamed up to offer a new 1-year fellowship for physicians interested in the multidisciplinary care of breast

PITTSBURGH--The University of Pittsburgh Cancer Institute’s Division of Behavioral Medicine and Oncology is seeking young women with breast cancer for a research study on helping families cope with cancer.

Women are more likely to start getting regular mammograms if health information is tailored to their personal concerns, according to the results of a Brown University study.

LONDON--Interim analyses of two randomized European trials of tamoxifen (Nolvadex) prophylaxis in healthy women have failed to show a significant reduction in the incidence of breast cancer, in contrast to the US Breast Cancer Prevention Trial (BCPT), which showed a 45% reduction with tamoxifen.

DALLAS--The Susan G. Komen Breast Cancer Foundation has announced the recipients of its 1998 postdoctoral fellowship grants, which total more than $1 million. In addition to these 10 new first-year grant recipients, the Komen Foundation currently funds 21 previously awarded fellowships throughout the United States.

LOS ANGELES--Avon’s Breast Cancer 3-Day is a new type of fundraising event--the first-ever multiday long distance walk. On October 23, 24, and 25, 1998, nearly 2,000 people in California will walk 50 to 60 miles (15 to 25 miles a day), beginning just south of Santa Barbara and ending just north of Malibu. Each participant has pledged to raise a minimum of $1,700 to support breast cancer awareness and education.

Researchers from the Pittsburgh-based National Surgical Adjuvant Breast and Bowel Project (NSABP) presented data on the Breast Cancer Prevention Trial (BCPT) during a plenary session of the recent American Society of Clinical Oncology

ATLANTA--The American Cancer Society is offering a "magalog," part magazine, part catalog, for women recovering from breast cancer and other cancers that involve treatment-related hair loss. Known as tlc (tender loving care), the nonprofit publication was created by Lana Leavitt Rosenfeld, an ACS volunteer.

PHILADELPHIA--The NCCN (National Comprehensive Cancer Network) has received a $1 million unrestricted grant from Genentech, Inc. The grant, provided over a 2-year period, will be used to support the development and expansion of the NCCN Oncology Outcomes Database with emphasis on breast cancer and non-Hodgkin’s lymphoma.

LOS ANGELES--For patients with refractory metastatic breast cancer, ideal therapy would offer palliation with ease of administration and limited side effects. The new agent capecitabine (Xeloda) can be taken orally at home, making it unique among currently available salvage regimens for metastatic breast cancer, Joanne L. Blum, MD, PhD, of Texas Oncology, Dallas, said at the 34th Annual Meeting of the American Society of Clinical Oncology (ASCO).

Predisposition testing (ie, genetic testing that provides information about a person’s susceptibility to disease) is now available for several inherited forms of cancer. Individuals who are found to have an altered gene (eg, a

WASHINGTON--The FDA’s On-cology Drugs Advisory Committee (ODAC) has recommended full approval of Rhône-Poulenc Rorer’s Taxotere (docetaxel) and a widening of the advanced breast cancer indication that received conditional approval in 1996, subject to completion of phase III trials.

University of California, San Francisco, researchers have received approval from the National Cancer Institute (NCI) to develop a less toxic breast cancer therapy that may also prove to be more efficient at directly targeting cancer cells.

Predisposition testing (ie, genetic testing that provides information about a person’s susceptibility to disease) is now available for several inherited forms of cancer. Individuals who are found to have an altered gene (eg, a

MILAN, Italy--Concern about the cardiotoxicity reported in early studies of AT--doxorubicin (Adriamycin)/paclitaxel (Taxol)--in advanced breast cancer was somewhat eased by a retrospective analysis of all previous AT studies.

LOS ANGELES--A monoclonal antibody directed at the HER2 receptor greatly enhances the effect of chemotherapy for women whose breast cancer overexpresses the HER2 gene. This encouraging finding comes as experts are beginning to suspect that increasing dose intensity of conventional chemotherapy may have "gone about as far as it can go," said Dennis Slamon, MD, PhD, chief, Division of Hematology-Oncology, UCLA School of Medicine.

EDMONTON, Alberta--Final results of a multicenter phase III trial show that docetaxel (Taxotere) improves survival more than mitomycin (Mutamycin)/vinblastine (MV) in anthracycline-resistant advanced breast cancer.

Women who adhere to a low-fat diet with plenty of vegetables and fruits may decrease their risk of developing breast cancer, according to a new study published in the May 1998 issue of The Journal of the American Dietetic Association. The study

CHICAGO--A monoclonal antibody expected to be approved by the FDA before year’s end is as potent as taxane therapy in certain virulent refractory breast cancers, according to research presented at an integrated symposium at the 34th Annual Meeting of the American Society of Clinical Oncology.

SAN FRANCISCO--Raloxifene (Evista), an estrogen-receptor modulator used to treat osteoporosis, also has a protective effect against breast cancer, according to a 2-year randomized study and an overview analysis reported at ASCO. These findings require some caution in interpretation, since they were mainly observed in women with osteoporosis, a population that has a lower breast cancer risk than the general population.

Mammotome biopsy causes significantly less internal breast scarring than open surgical biopsy and is less likely to interfere with a radiologist’s ability to read subsequent mammograms, according to a new study presented at the third annual

NEW YORK--Avon’s Breast Cancer Awareness Crusade is combining health and beauty with the introduction of its newest fundraising product, the Avon Pink Ribbon Cosmetics Case.

SAN FRANCISCO--Interim results of a major intergroup study of paclitaxel (Taxol) as adjuvant treatment of node-positive breast cancer "will change the standard of care for node-positive breast cancer patients," I. Craig Henderson, MD, of the University of California, San Francisco, said at ASCO.