Commentary (Czito/Willett): Neoadjuvant Therapy for Gastric Cancer
August 01, 2005
Drs. Chadha, Kuvshinoff, andJavle have provided a wellwrittenreview of the rationaleand literature supporting neoadjuvanttherapy and gastric cancer.Although the incidence of gastric canceris declining in the United States,approximately 1 million new caseswill be diagnosed worldwide this yearwith over 700,000 deaths, resulting ina disease-related mortality of nearly75%. These figures emphasize theneed for new and improved treatmentstrategies in this disease. In contrastto other gastrointestinal malignancies,there has been little systematic evaluationof neoadjuvant multimodalityapproaches for patients with gastriccancer. Given its natural history andbiology, this approach is logical andmay yield therapeutic benefit.