Blowing Smoke: The Lost Legacy of the 1964 Surgeon General’s Report on Smoking and HealthMay 15th 2014
The 50th anniversary of the Surgeon General’s Report on Smoking and Health is not a time for celebration, but rather one of sober reflection about missed opportunities. Our progress in reducing the prevalence of smoking is undeniable, but our current efforts have become more symbol than substance.
Addressing the Common Mystery of the Solitary Pulmonary NoduleMay 15th 2014
To ultimately find what we are actually looking for, the invasive malignant nodule in a haystack of benign lesions, new strategies and qualitative and quantitative tools are needed to propel noninvasive evaluation of solitary pulmonary nodules into the 21st century.
Friend or Foe: The Bifunctional Role of Steroid Hormones in Prostate CancerMay 15th 2014
While the multifunctional role of steroid hormones in prostate cancer and men’s health was recognized early, the apparent clinical benefit afforded by ADT tipped the scales in favor of androgen deprivation in men with advanced prostate cancer.
PET Scanning: Worth the Cost in Cancer? Not for All Cancers-It’s Not Reliable Enough YetMay 15th 2014
In order for a test to be reliable, it must be reproducible and minimize test-retest variability. Yet, as with many imaging tests, FDG-PET has variance in standard uptake value (SUV) calculations, and even if standardization could be achieved, there is the issue of treatment effects, which introduce additional complexities.
Leptomeningeal Enhancement in a 58-Year-Old WomanMay 15th 2014
The patient is a 58-year-old woman who was diagnosed at an outside hospital with a World Health Organization (WHO) grade III non–contrast-enhancing right frontal anaplastic astrocytoma, with spread into the genu of the corpus callosum.
Following the Data: Past, Present, and Future Management of the Axilla in Breast Cancer PatientsMay 15th 2014
Validation of sentinel lymph node (SLN) dissection (SLND) as an alternative to axillary lymph node dissection (ALND) has been a significant advance in the surgical management of breast cancer.
Whole-Body PET Imaging of Breast Cancer Characteristics to Improve Precision TreatmentMay 15th 2014
However, it is becoming ever clearer that tumor characteristics can change during the course of disease. Given this change over time, other supporting techniques for guiding therapy would be of value. Molecular radionuclide imaging with positron emission tomography (PET) can potentially fulfill this need.
Low-Dose Spiral CT Screening and Evaluation of the Solitary Pulmonary NoduleMay 15th 2014
The number of lesions detected with low-dose CT, only some of which are early cancers, is so great that algorithms are being developed for more efficient evaluation and management of solitary pulmonary nodules. This article will discuss current tools, approaches, and concerns regarding patient care in this setting.
Using Nuclear Medicine Imaging in Clinical Practice: Update on PET to Guide Treatment of Patients With Metastatic Breast CancerMay 15th 2014
We review how radiolabeled glucose and estrogen analogs can be used in breast cancer patients. We focus this review on the application of positron emission tomography imaging to ER-positive metastatic breast cancer as an example of how imaging can guide breast cancer treatment.
Management of the Clinically Node-Negative Axilla: What Have We Learned From the Clinical Trials?May 15th 2014
Here we review the evolution of sentinel lymph node biopsy for the management of clinically node-negative breast cancer, and we address the current controversies and management issues.