Oncology Vol 28 No 5

Blowing Smoke: The Lost Legacy of the 1964 Surgeon General’s Report on Smoking and Health

May 15, 2014

The 50th anniversary of the Surgeon General’s Report on Smoking and Health is not a time for celebration, but rather one of sober reflection about missed opportunities. Our progress in reducing the prevalence of smoking is undeniable, but our current efforts have become more symbol than substance.

Addressing the Common Mystery of the Solitary Pulmonary Nodule

May 15, 2014

To ultimately find what we are actually looking for, the invasive malignant nodule in a haystack of benign lesions, new strategies and qualitative and quantitative tools are needed to propel noninvasive evaluation of solitary pulmonary nodules into the 21st century.

Friend or Foe: The Bifunctional Role of Steroid Hormones in Prostate Cancer

May 15, 2014

While the multifunctional role of steroid hormones in prostate cancer and men’s health was recognized early, the apparent clinical benefit afforded by ADT tipped the scales in favor of androgen deprivation in men with advanced prostate cancer.

PET Scanning: Worth the Cost in Cancer? Not for All Cancers-It’s Not Reliable Enough Yet

May 15, 2014

In order for a test to be reliable, it must be reproducible and minimize test-retest variability. Yet, as with many imaging tests, FDG-PET has variance in standard uptake value (SUV) calculations, and even if standardization could be achieved, there is the issue of treatment effects, which introduce additional complexities.

Leptomeningeal Enhancement in a 58-Year-Old Woman

May 15, 2014

The patient is a 58-year-old woman who was diagnosed at an outside hospital with a World Health Organization (WHO) grade III non–contrast-enhancing right frontal anaplastic astrocytoma, with spread into the genu of the corpus callosum.

Whole-Body PET Imaging of Breast Cancer Characteristics to Improve Precision Treatment

May 15, 2014

However, it is becoming ever clearer that tumor characteristics can change during the course of disease. Given this change over time, other supporting techniques for guiding therapy would be of value. Molecular radionuclide imaging with positron emission tomography (PET) can potentially fulfill this need.

Low-Dose Spiral CT Screening and Evaluation of the Solitary Pulmonary Nodule

May 15, 2014

The number of lesions detected with low-dose CT, only some of which are early cancers, is so great that algorithms are being developed for more efficient evaluation and management of solitary pulmonary nodules. This article will discuss current tools, approaches, and concerns regarding patient care in this setting.

Using Nuclear Medicine Imaging in Clinical Practice: Update on PET to Guide Treatment of Patients With Metastatic Breast Cancer

May 15, 2014

We review how radiolabeled glucose and estrogen analogs can be used in breast cancer patients. We focus this review on the application of positron emission tomography imaging to ER-positive metastatic breast cancer as an example of how imaging can guide breast cancer treatment.