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Dr. Blum has written a comprehensive summary of the natural history, pathology, prevention, and management of anthracycline-induced cardiotoxicity. His excellent state-of-the-art review updates readers on most of the recent advances in this field.

There are many challenges facing those involved in chemotherapy drug development. In addition to identification of new agents, clinical investigators must address questions regarding the optimal methods of administration of established agents so as to maximize efficacy and minimize toxicity. Treatment toxicity affects not only morbidity and mortality but also issues of dose intensity, quality of life, and health-care costs. Therefore, there is great interest in preventing the side effects associated with chemotherapy.

Over the past 10 years, the Radiation Therapy Oncology Group has evaluated, by Phase III trials, the value of using a combination regimen, including androgen suppression (goserelin [Zoladex] and flutamide [Eulexin]) and radiation therapy, in locally advanced prostate cancer. Androgen suppression prior to or during radiation has not been shown to increase overall survival, but it has been shown to increase progression-free survival and freedom from distant metastases. In addition, a subset of men with poorly differentiated tumors who received goserelin following external beam radiation have had a significant overall survival benefit at 5 years’ follow-up. [Oncol News Int 6(Suppl 3):19-20, 1997]

Androgen deprivation has been used prior to radical prostatectomy in an attempt to improve local control of prostate cancer and delay time to cancer progression. Thirty men (mean age of 65) with clinical stage T3 adenocarcinoma of the prostate were entered into a phase II trial at the University of California, San Francisco, examining the effects of neoadjuvant androgen deprivation (luteinizing hormone-releasing agonist and an antiandrogen) before radical prostatectomy. Twenty-six of these patients subsequently underwent radical prostatectomy. Despite impressive physiological changes in prostate and tumor volume, stage reduction was noted in only 4 patients (15%). Overall, with a mean follow-up of 32.7 months, 72% of patients had evidence of disease recurrence, including detectable PSA. Several series suggest that in patients with stage T1 and T2 disease, the likelihood of a positive surgical margin after radical prostatectomy is decreased substantially by neoadjuvant deprivation. The effect on long-term disease-free survival, however, is still unknown. [Oncol News Int 6(Suppl 3):16-17, 1997

CHICAGO-A recurring theme voiced by members of the oncology community throughout a two-day conference on purchasing oncology services was the need for payers to financially support the participation of cancer patients in NCI-sanctioned clinical trials.

PHILADELPHIA-Fine needle aspiration (FNA) for breast cytology has a false-positive incidence “very close to zero,” Nadia Al-Kaisi, MD, said in an interview with Oncology News International. “For the past several years,” she said, “the accuracy has increased because of increased recognition of the cytologic features of the various benign and malignant lesions.”

MELVILLE, NY--Fonar Corporation has received a patent for new technology in the design of MRI machines for breast exams. By using a high throughput scanner, the company said, the machine should be able to achieve the patient volumes necessary to make MRI more affordable, possibly with scans as low as $80 to $150 versus the current $700 to $1,200.

BETHESDA, Md-Thalidomide could be increasingly used off-label to treat several cancers and other diseases if the Food and Drug Administration takes the advice of an advisory committee and, for the first time, approves the agent for marketing in the United States.

ATLANTA-Is there any value to yet another debate on screening mam-mography for women aged 40 to 49? Maybe so when one of the speakers is a breast cancer survivor whose disease was diagnosed mammographically at age 39. Especially since that speaker-Frances M. Visco, JD-spoke against universal mammographic screening for younger women.

BETHESDA, Md-The low-fat message isn’t reaching America’s children. A National Cancer Institute analysis finds that, on average, children consume 35% of their calories as fat and that this figures holds across age, sex, ethnic, and income categories.

RAHWAY, NJ-To help serve an increasingly health-conscious public, Merck & Co. has launched its first consumer reference, The Merck Manual of Medical Information-Home Edition.

BETHESDA, Md-Richard D. Klausner, MD, became the 11th director of the National Cancer Institute on Aug. 1, 1995. He took over a troubled organization, one torn by accusations of scientific misconduct against several of its researchers and grantees and the target of two critical evaluations.

The usefulness of doxorubicin (Adriamycin) in the treatment of a variety of malignancies is limited by its concomitant toxicity. The encapsulation of chemotherapeutic agents, including doxorubicin, in

SAN FRANCISCO-Most patients with squamous cell carcinoma (SqCC) of the head and neck are elderly, and this group has been well represented in studies of the disease, which generally include few patients under the age of 40, said Peter Lacy, MB, FRCSI, a fellow at the Clinical Outcomes Research Office, Washington University Medical Center (WUMC), St. Louis.

WASHINGTON-Does President Clinton’s stand on the tobacco settlement threaten to scuttle the agreement between the tobacco industry and the attorneys general of 40 states?

BOSTON-Two reports have confirmed the value of the so-called HIV cocktail, three-drug combinations that appear to restore immune function in people infected with HIV, at least temporarily. With such treatments available, many believe that the time has come to push for more HIV testing and reporting, so that people can get treatment early when it is most likely to be effective.

BETHESDA, Md-For the second time in as many meetings, the Oncologic Drugs Advisory Committee (ODAC) has recommended that the FDA approve a paclitaxel-based drug for the treatment of AIDS-related Kaposi’s sarcoma (KS).

PITTSBURGH-Bernard Fisher, MD, Distinguished Service Professor at the University of Pittsburgh, has accepted an apology and cash settlement from the University of Pittsburgh, and withdrawn his defamation suit against the University and the federal government.

WILMINGTON, Del-The FDA has cleared an alternative method of administration of the pellets contained in Zeneca’s Kadian (morphine sulfate sustained release) capsules.

MENLO PARK, Calif-Researchers have cloned a critical component of the human telomerase gene-the catalytic protein subunit. Some scientists view the finding as the “holy grail” of cell aging research.

The fiscal year (FY) 1998 Balanced Budget Act contains several important changes in the Medicare program that affect physicians, including a go-ahead for provider-sponsored organizations (PSOs) (closed networks run by hospitals, doctors, and other providers instead of insurance companies) and new opportunities for the private sector to compete in the Medicare+Choice plans.

Albert H. Owens, Jr, MD, President of the National Coalition for Cancer Research (NCCR), urged the National Cancer

GLASGOW-Gamma camera molecular coincidence detection (MCD) technology allows imaging of positron-emitting radiotracers such as FDG without the need for a dedicated PET scanner, and thus should make FDG imaging much more widely available, Henry N. Wagner, Jr., MD, professor of radiation health sciences at Johns Hopkins Medical Institutions, told Oncology News International.

SAN FRANCISCO-Treatment practices often vary in the United States between physicians and across geographic regions, and such variation may be more likely when definitive comparisons of treatment modalities are lacking, as is the case with the management of early laryngeal carcinoma.

Researchers at The M.D. Anderson Cancer Center and Memorial Sloan-Kettering are embarking on a study that may evolve

IDYLLWILD, Calif-Actor Dustin Hoffman joined “Ronald McDonald,” the McDonald’s restaurant clown, and nearly 100 campers and their families in celebrating the 15th anniversary of Camp Ronald McDonald for Good Times-one of the nation’s oldest and largest year-round recreational camping programs for children with cancer.

WASHINGTON-The Federal Trade Commission (FTC) is proposing a new set of measurements to gauge the tar and nicotine yields of cigarettes.

LOS ANGELES-The Lymphoma Research Foundation of America launched its second annual National Lymphoma Awareness Week on October 12. Actress Kelly Lynch, whose sister Robyn Lynch is a lymphoma survivor, served as honorary chair of the week, which featured a slate of events to inform the public about this cancer.

Clinical data supporting the use of leukocyte-reduced blood indicates a significant decrease in the risk of infection and cost of recovery in surgical patients, according to a panel of experts.

NEW YORK-A strong belief in the healing power of creative activity spurred Geraldine Herbert to establish a place where women with cancer could go to express themselves through the visual, performing, literary, and domestic arts-The Creative Center for Women With Cancer, located in New York City.