FDA Grants Priority Review to Trastuzumab Deruxtecan for HER2+ Metastatic Breast Cancer
The agency is set to make a decision on the investigational antibody drug conjugate by the first quarter of 2020.
The Prognostic Importance of EVI1 Expression
Researchers explore the predictive capability of EVI1 expression.
Trial Explores New Drug for AML
Researchers report on the BRIGHT AML 1019 Phase III trial.
Lack of Patient Understanding of PFS Points to Bigger Issues
A study showed patients seem to lack an understanding of the meaning of progression-free survival.
Safety, Efficiency of Pembrolizumab Monotherapy in Geriatric PD-L1+ NSCLC
A pooled analysis of safety, efficacy of pembrolizumab in patients 75+ years of age with PD-L1+ NSCLC
UPenn Algorithm Prioritizes Cancer Mutations for Immunotherapy
The neoantigens found in the patients’ tumors (non-small-cell lung cancer) which were highly dissimilar were enriched for hydrophobic sequences, and correlated with survival rates after the PD-1 checkpoint therapy.
Pancreatic Cancer: What the ESPAC-4 Randomized Adjuvant Chemotherapy Trial Tells Us
Researchers examine patterns of recurrence after resection of pancreatic ductal adenocarcinoma.
Israeli Study Finds Immunotherapies Increase Risk of Acute Vascular Events
Following administration of checkpoint inhibitor therapy, 2.6% of patients experienced an acute vascular event within 6 months of starting treatment.
Follow-Up Investigation Highlights Need to Better Understand Ibrutinib-Associated Toxicities
A study found an association between treatment with ibrutinib and an increased risk for death from toxicities.
Nobel Prize in Medicine Awarded to Three For Oxygen Regulation Linked to Cancers
Three scientists were awarded the Nobel Prize in Physiology of Medicine for their discovery of the mechanism of how cells regulate oxygen.
Carcinoma of the Anal Canal: A Feasibility Study
A multi-institutional pilot feasibility study looks at pencil beam scanning proton beam chemoradiation therapy with 5-fluorouracil and mitomycin-C for definitive treatment of carcinoma of the anal canal.
Social Media Recruiting for Trials Falls Short
A survey of physicians found recruiting for trials through social media can be useful, but not for cancer therapeutic trials.
Novel Combination Treatment for Differentiated Thyroid Cancer
Researchers look at how mutation status can influence responses to targeted therapy in thyroid cancer.
Pembrolizumab and PFS in Advanced Melanoma
Researchers report on the best pembrolizumab protocol for advanced melanoma.
Sentinel Node Biopsy in Clinical Stage I Testicular Cancer
Investigators report on long-term results of sentinel node (SN) approach in patients with clinical stage I testicular tumors.
Study Finds High Number of European Cancer Drug Trials at Risk for Bias
Half of the cancer drug trials that led to approvals by the European Medicines Agency may have been associated with a high risk for bias.
FDA Grants Breakthrough Therapy Designation to Niraparib for mCRPC
The agency granted breakthrough therapy designation to niraparib for the treatment of men with BRCA1/2-mutant positive metastatic castration-resistant prostate cancer.
Role of COX7RP in Endometrial, Breast Cancer Growth
COX7RP contributes to endometrial and breast cancer growth.
Three-Drug Palliative Chemotherapy Regimen Shows Promise for Advanced Oral Cancer
The methotrexate-based regimen proved to lengthen survival and improve quality of life among patients with platinum-resistant oral cancer.
PD-L1 Inhibition Plus Pegilodecakin Active in Advanced Solid Tumor All-Comers
A combination of pegilodecakin (pegylated IL-10) with an anti-PD-L1 monoclonal antibody inhibitor showed preliminary antitumor activity.
Prognostic Value of Intraoperative Bile Spillage in Gallbladder Adenocarcinoma
Intraoperative bile spillage might serve as a prognostic tool for gall bladder cancer.
Analysis of Cervical Mutations Aids Endometrial Cancer Diagnosis
Diagnosis of endometrial carcinoma made easier by analysis of mutations in cervix or endometrial tissue.
Oncologists Responsive to FDA Label Restrictions
After the FDA restricted the labels of 2 drugs used to treat bladder cancer, oncologists' use of these treatments decreased drastically.
Unexpected Uterine Cancer: Power Morcellation and Mortality
Coffee and Pancreatic Cancer Risk Among Never-Smokers
Researchers believe that previous findings about coffee consumption’s possible link to an increased risk of pancreatic cancer come from confounding factors that were not accounted for, such as smoking.
Germline Investigation in Male Breast Cancer
Although rare, is breast cancer in males genetic? Researchers provide details.
Incidence of Non-Melanoma Skin Cancer Tallies Biggest Change From 2016 to 2017
The Global Burden of Disease 2017 study found non-melanoma skin cancer to be the biggest increase in incidence worldwide.
FDA Approves Darzalex Combo as Frontline Treatment for Myeloma
The combination use of Darzalex with bortezomib, thalidomide, and dexamethasone was approved for transplant-eligible patients with multiple myeloma.
What Percentage of Cancer Diagnoses Are Made in the Emergency Department?
Some patients are more likely to find out about their cancer via a visit to the emergency department than others.
FDA Expands Indicated Age Range for CRC Screening Tool
As more younger adults are diagnosed with colorectal cancer, the FDA approved Cologuard, a stool-based, at-home colorectal cancer screening, for adults aged 45 to 49 years.
