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A novel drug that targets an important protein receptor that supports B-cell lymphoma cells produced significant responses in non-Hodgkin’s lymphoma patients who had failed prior therapies. Results from the phase II trial of fostamatinib disodium in 68 heavily pretreated relapsed and refractory B-cell NHL patients revealed that the treatment has significant promise and should undergo further clinical testing, according to lead investigator Jonathan W. Friedberg, MD, of the James P. Wilmot Cancer Center at the University of Rochester in New York.

Recipients of the 2009 ASCO Special Awards have been announced. Clara D. Bloomfield, MD, (left) will be given the David A. Karnofsky Memorial Award; the Science of Oncology Award will go to Bert Vogelstein, MD; Olufunmilayo Olopade, MBBS, will receive the ASCO-American Cancer Society Award; the B.J. Kennedy Award for Scientific Excellence in Geriatric Oncology will be given to Martine Extermann, MD, PhD; the Pediatric Oncology Award will be presented to William E. Evans, PharmD, and Mary V. Relling, PharmD; John H. Glick, MD, will take home the Distinguished Achievement Award; Diane S. Blum, MSW, is the recipient of Partners in Progress Award; Richard Pazdur, MD, will be given the Special Recognition Award.

As comparative effectiveness research matures from a political buzz phrase to a decision-making process, leaders in the oncology community are concerned about the effect this latest government initiative might have on community practices that already feel overregulated.

One of the most discussed elements of President Obama's health-care reform is the the initiative to launch comparative effectiveness research. The administration contends that CER is about enhancing the quality of care by choosing more effective clinical options. Pharma is worried that comparative effectiveness code for cost-effectiveness, and oncologists are concerned that CER could effect the autonomy of their clinical decision making.

New biologics are improving the treatment of advanced colorectal cancer, but their optimal integration into practice remains unclear, and the question of how aggressive treatment should be is still open ended.

ASCO has issued policy recommendations designed to eliminate existing disparities between minorities and whites, and between those with and without health insurance. “Disparities in Cancer Care” comes as the incidence of cancer is projected to increase significantly in the next 20 years, a situation that could be catastrophic if not dealt with sooner rather than later.

A call center in India takes a customer service inquiry from Idaho; an Australian doctor reads an emergency x-ray for a U.S. patient; a professor in Moscow delivers a lecture via satellite to UK-based students-these examples of “going global” no longer seem so novel. Cancer clinical trials are also crossing international datelines. Between 2005 and 2006, international clinical trials initiated in the Asia-Pacific region increased by 50%, while major research initiatives-once the stronghold of U.S. institutions-are now run by EU-based investigators.

Imaging with MR and/or PET/CT can help physicians figure out appropriate treatment for cervical cancer patients as well as prevent unnecessary therapy, according to a new study.

V. Craig Jordan, OBE, PhD, DSc, will become the scientific director for the cancer center and vice chairman of the department of oncology at Georgetown University Medical Center and the Lombardi Comprehensive Cancer Center.

Elekta has promised $1 million to the Radiation Oncology Institute, a campaign spearheaded by the American Society for Radiation Oncology to raise awareness of radiation therapy.

Varian gains more worldwide sites for RapidArc system

ORLANDO, Fla.-ASCO has awarded $10,000 grants to five state projects. The recipients will be recognized at the State Affiliates’ Reception at ASCO 2009.

Acupressure wristbands help cancer patients who are nauseous from radiation treatment, according to a study in the Journal of Pain and Symptom Management.

Homeopathy can help cancer patients with skin irritation and mouth sores, according to a review involving 664 participants published in the Cochrane Database of Systematic Reviews (online issue 2, 2009).

A cancer diagnosis carries with it a unique set of challenges for patients, their family, and healthcar e professionals. Patients newly diagnosed with cancer and their support people are frequently in shock, fearful, and emotionally regressed.

Recently released, the 2009 Medicare Trustees report projected that Medicare, the primary insurance carrier for much of the nation's cancer population, is in deep fiscal trouble. Amidst the clamor on Capitol Hill for revamping our health-care system, the daunting challenge of Medicare's dilemma is largely left off the table. Silence on this issue threatens our ability to deliver high-quality cancer care to our aging population.

Common logic among the public dictates that it is grossly unfair to deny a person dying of cancer access to an experimental therapy that might be the person's last hope. The blame usually falls on FDA and Pharma; politics and greed are the common back-stories behind this very real , and largely misunderstood issue.

Despite the widespread perception that herbal products are safe because they are “natural,” few of these products have been subjected to rigorous research. The potential risks associated with many herbal dietary supplements remain unknown.

Preface

About This Treatment Guide

A mobile MRI unit recently pulled up to the steps of Capitol Hill, launching the Brain Tumor Foundation's national campaign for early detection. Led by the Foundation's president and founder, Patrick J. Kelly, MD, free brain scans were offered to members of Congress and their staff, along with government officials. Good intentions aside, the effort was derided as doing more harm than good by many leading cancer experts.

In a decision that many in the oncology community view as penny-wise, dollar-foolish, CMS reversed its decision to cover CT colonograhpy as a screening tool in colorectal cancer. Proponents of CT colonography contend that the less invasive nature promotes adherence to regular screening; critics say CT colonography's inability to remove polyps creates unnecessary redundancy; if polys are detcted the gold standard optical method is then needed. Why not just do it the first time?

A substantial number of cancer patients turn to unconventional agents used as anticancer therapies. However, “alternative cures” are unproved and may be harmful. They are not supported by clinical research and they can jeopardize patients’ lives, especially when patients delay needed care. Amygdalin, promoted as a popular alternative cancer cure for over 40 years, is used by many cancer patients. No solid data supports its effectiveness.

A multi-institutional group has validated a predefined 1,550-gene expression profile for identifying tumor tissue of origin. Malignancies found in unexpected locations, or with poorly differentiated morphologies, can pose a challenge for tissue of origin determination.

Women’s healthcare company Hologic received FDA premarket approval for Cervista HPV HR test and the Cervista HPV 16/18 test. The tests are manufactured by Third Wave Technologies. The high-risk Cervista HPV HR test has been approved to screen patients with atypical squamous cells of undetermined significance from cervical cytology results and determine the need for referral to colposcopy. It can also be used adjunctively with cervical cytology to screen women 30 years and older to assess the presence or absence of high-risk HPV types.

Asian-American women who consumed large amounts of soy as children have a 58% reduced risk of breast cancer, according to a study conducted at National Cancer Institute’s Clinical Genetics Branch.

Researchers have identified a possible genetic cause for an increased risk for a more advanced form of colorectal cancer in blacks that leads to shorter survival, according to data published in Clinical Cancer Research (15:2406-2416, 2009).

A large meta-analysis of individual patient data from clinical trials of ESAs in cancer patients found that ESAs increased on-study mortality by 17% and overall survival by 6% in patients randomized to receive ESAs, compared with controls. When patients who were on chemotherapy were analyzed separately, the increased risk in on-study mortality and overall survival with ESAs was less pronounced, but cannot be excluded, said Dr. Bohlius from the University of Bern, Switzerland.

As yoga continues to grow in popularity worldwide, questions regarding its use as a therapeutic modality are becoming increasingly important,” said Dr. Dhruva, who is an assistant clinical professor at the University of California, San Francisco and at the UCSF Osher Center for Integrative Medicine.