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Opinion|Videos|February 23, 2024

Advancements in Treating Brain Metastases in HER2+ Breast Cancer

Author(s)Carey K. Anders, MD, Heather Moore, CPP, PharmD, Rani Bansal, MD

Rani Bansal, MD, discusses progressive developments in treating brain metastases in HER2-positive breast cancer, highlighting insights from the TUXEDO and DEBORAH trials, and examines the potential role of T-DXd in managing leptomeningeal disease.

Episodes in this series

A panel of 4 experts on breast cancer seated at a long table

EP. 1 Advancements in Treatment Strategies for HER2+ Metastatic Breast Cancer: Insights from Experts at the Duke Cancer Center

Susan Dent, MD, an expert on breast cancer

EP. 2 Approaches for 1L Therapy and Restaging in Triple-Positive mBC

A panel of 4 experts on breast cancer

EP. 3 The Role of Radiotherapy in HER2+ mBC

Susan Dent, MD, an expert on breast cancer

EP. 4 Treatment Approaches for Triple-Positive mBC in the 2L Setting and Beyond

Heather Moore, CPP, PharmD, an expert on breast cancer

EP. 5 Treatment Considerations and AE Management Strategies with HER2-Directed Therapies

Carey Anders, MD, an expert on breast cancer

EP. 6 Patient Case Presentation: A 34-Year-Old Woman with HER2+ mBC and Brain Metastases

A panel of 4 experts on breast cancer

EP. 7 HER2CLIMB: Targeting Stable and Active Brain Metastases in Advanced HER2+ Breast Cancer

Carey Anders, MD, an expert on breast cancer

EP. 8 BRIDGET: Preventing Secondary Brain Metastases in Advanced HER2+ Breast Cancer

Heather Moore, CPP, PharmD, an expert on breast cancer

EP. 9 Strategies for AE Management with Tucatinib in Breast Cancer

A panel of 4 experts on breast cancer seated at a long table

EP. 10 D-TORCH: Topical Diclofenac for Reducing Hand Foot Syndrome with Capecitabine

Rani Bansal, MD, an expert on breast cancer

EP. 11 Patient Case Presentation: A 34-Year-Old Woman with HER+ mBC and Brain Metastases

A panel of 4 experts on breast cancer seated at a long table

EP. 12 Advancements in Treating Brain Metastases in HER2+ Breast Cancer

A panel of 4 experts on breast cancer seated at a long table

EP. 13 Radiation Necrosis with ADCs and Concurrent Radiotherapy for Brain Metastases

A panel of 4 experts on breast cancer seated at a long table

EP. 14 Strategies for AE Management with T-DXd in Breast Cancer

A panel of 4 experts on breast cancer seated at a long table

EP. 15 Looking Ahead: Future Perspectives and Unmet Need in HER+ Breast Cancer

Carey K. Anders, MD, an expert on breast cancer

EP. 16 Recent Data from KATHERINE and APHINITY in HER2+ Breast Cancer

Carey Anders, MD, an expert on breast cancer

EP. 17 Updates from HER2CLIMB in HER2+ Metastatic Breast Cancer

Carey Anders, MD, an expert on breast cancer

EP. 18 BRIDGET Study: Tucatinib Plus HER2-Directed Antibody Therapy in Breast Cancer

Carey Anders, MD, an expert on breast cancer

EP. 19 Future Perspectives on HER2+ Breast Cancer Treatment

EP. 20 Applying Updated Findings From SABCS 2023 to HER2+ Breast Cancer Practice

EP. 20 Applying Updated Findings From SABCS 2023 to HER2+ Breast Cancer Practice

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Stay up to date on recent advances in the multidisciplinary approach to cancer.

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Eileen M. O’Reilly, MD; E. Gabriela Chiorean, MD, FASCO; Michael J. Pishvaian, MD, PhD; Brian Wolpin, MD, MPH

Medical Crossfire®: Integrating Next-Generation Endocrine Targeting Therapies to Improve Outcomes for Patients With HR+/HER2- Breast Cancer

Medical Crossfire®: Integrating Next-Generation Endocrine Targeting Therapies to Improve Outcomes for Patients With HR+/HER2- Breast Cancer

William J. Gradishar, MD, FASCO, FACP; Laura Huppert, MD; Yuan Yuan, MD, PhD

Breast Cancer Tumor Board: Targeting TROP2 – Innovations in Triple-Negative Breast Cancer Treatment

Breast Cancer Tumor Board: Targeting TROP2 – Innovations in Triple-Negative Breast Cancer Treatment

Joyce O’Shaughnessy, MD; Matthew P. Goetz, MD; Hope S. Rugo, MD, FASCO

Expert Guidance on Frequently Asked Questions Regarding the Use of ADCs in TNBC

Expert Guidance on Frequently Asked Questions Regarding the Use of ADCs in TNBC

Aditya Bardia, MD, MPH, FASCO; Erika P. Hamilton, MD; Virginia Kaklamani, MD, DSc

Evaluating the Latest Data and Ongoing Trials for Novel ADC Approaches in TNBC

Evaluating the Latest Data and Ongoing Trials for Novel ADC Approaches in TNBC

Aditya Bardia, MD, MPH, FASCO; Erika P. Hamilton, MD

Dissecting Clinical Trial and Real-World Data for ADCs in TNBC

Dissecting Clinical Trial and Real-World Data for ADCs in TNBC

Filipa Lynce, MD; Rita Nanda, MD

Breaking Down the Rationale for Targeting TROP2 in TNBC

Breaking Down the Rationale for Targeting TROP2 in TNBC

Filipa Lynce, MD; Rita Nanda, MD

Cross-Disease Integration of Immunotherapy Innovations

Cross-Disease Integration of Immunotherapy Innovations

Ghassan Abou-Alfa, MD, MBA; Laura Williams Goff, MD, MSCI, MMHC, FASCO; Arndt Vogel, MD, PhD

PER Resource Center: Integrating Novel Approaches in TNBC – New Avenues for TROP2-Targeting ADCs and Beyond – Nursing

PER Resource Center: Integrating Novel Approaches in TNBC – New Avenues for TROP2-Targeting ADCs and Beyond – Nursing

Aditya Bardia, MD, MPH, FASCO; Erika P. Hamilton, MD; Virginia Kaklamani, MD, DSc; Filipa Lynce, MD; Rita Nanda, MD; Tiffany A. Traina, MD, FASCO

Medical Crossfire® in Adjunctive Testing: Charting a New Course in Prostate Cancer Risk Assessment

Medical Crossfire® in Adjunctive Testing: Charting a New Course in Prostate Cancer Risk Assessment

Jason Hafron, MD; Aaron D. Berger, MD; Arpeet Shah, MD

Community Practice Connections™: Enhancing Melanoma Outcomes With Intratumoral Oncolytic Immunotherapy–Strategies for the Multidisciplinary Team

Community Practice Connections™: Enhancing Melanoma Outcomes With Intratumoral Oncolytic Immunotherapy–Strategies for the Multidisciplinary Team

Yana G. Najjar, MD; Sapna Patel, MD

Community Practice Connections™: Optimizing SCLC Treatment Strategies and Managing Adverse Events Across Disease Stages

Community Practice Connections™: Optimizing SCLC Treatment Strategies and Managing Adverse Events Across Disease Stages

Erminia Massarelli, MD, PhD, MS; Misty D. Shields, MD, PhD

Navigating the Adverse Event Landscape in HER2+ GEA Therapy

Navigating the Adverse Event Landscape in HER2+ GEA Therapy

Rahul Gosain, MD, MBA; Rohit Gosain, MD; Geoffery Ku, MD; Shruti Patel, MD

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