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|Articles|June 19, 2009

Oncology NEWS International

  • Oncology NEWS International Vol 18 No 6
  • Volume 18
  • Issue 6

ALK-1 receptor: New target in angiogenesis

Pfizer Oncology is working with a fully human, IgG2 monoclonal antibody (PF-03446962) that is directed against an activin-like receptor kinase 1 (ALK-1) target. An early investigation indicates that neutralizing ALK-1 with PF-03446962 can disturb tumor endothelial cell function and impair tumor angiogenesis, according to the company (AACR 2009 abstract 2007).

Pfizer Oncology is working with a fully human, IgG2 monoclonal antibody (PF-03446962) that is directed against an activin-like receptor kinase 1 (ALK-1) target. An early investigation indicates that neutralizing ALK-1 with PF-03446962 can disturb tumor endothelial cell function and impair tumor angiogenesis, according to the company (AACR 2009 abstract 2007).

Articles in this issue

about 17 years ago

ADT in prostate ca increases risk of bone and heart complications

about 17 years ago

Abraxis backs SPARC as prognostic biomarker

about 17 years ago

Abraxane prolongs PFS in metastatic disease

about 17 years ago

SAVI applicator removes obstacles associated with brachytherapy

about 17 years ago

Mistrust, costs reduce breast cancer screening among minorities

about 17 years ago

Oral chemotherapy poses more challenges for cancer community

about 17 years ago

CMS nixes CT colonography screening

about 17 years ago

New ultrasound strategy helps pinpoint prostate tumors

about 17 years ago

New research on VEGF, gene mutations refines understanding of tumor angiogenesis

about 17 years ago

From the ONI archives: Should low-dose induction dexamethasone be standard of care in multiple myeloma?

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