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Opinion|Videos|November 25, 2025

Assessing ctDNA-Guided Therapy in MIBC in IMvigor011

Author(s)Joshua J. Meeks, MD, PhD, BS, Alan Tan, MD

The discussion centers on the Imvigor011 trial, comparing its ctDNA-guided intervention approach to prostate cancer monitoring. Dr. Meeks and Dr. Tan explore how this prospective study could transform adjuvant therapy strategies in muscle-invasive bladder cancer (MIBC).

Episodes in this series

Two experts are featured in this series.

EP. 1 Challenges in MIBC Management and Opportunities for ctDNA-based Testing

EP. 2 Exploratory Analysis of ctDNA in MIBC from CheckMate 274

EP. 2 Exploratory Analysis of ctDNA in MIBC from CheckMate 274

Two experts are featured in this series.

EP. 3 Evaluating ctDNA Biomarkers in MIBC from SunRISe-4

Two experts are featured in this series.

EP. 4 Opportunities for Guiding Neoadjuvant Treatment Decisions with ctDNA in MIBC

Two experts are featured in this series.

EP. 5 Assessing ctDNA-Guided Therapy in MIBC in IMvigor011

Two experts are featured in this series.

EP. 6 Implications for ctDNA-Guided Adjuvant Decision-Making in MIBC

The discussion centers on the Imvigor011 trial, comparing its ctDNA-guided intervention approach to prostate cancer monitoring. Dr. Meeks and Dr. Tan explore how this prospective study could transform adjuvant therapy strategies in muscle-invasive bladder cancer (MIBC). They analyze the trial's potential to validate ctDNA as both a prognostic and predictive tool, discussing its implications for personalized treatment. The experts examine how molecular monitoring might revolutionize clinical decision-making, offering a more dynamic approach to patient management. Their conversation highlights the growing significance of molecular testing in understanding disease progression and treatment response. They critically assess the trial's methodology, exploring how ctDNA-guided interventions could provide more precise, individualized treatment strategies. The discussion underscores the potential of advanced molecular diagnostics to improve patient outcomes.

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Stay up to date on recent advances in the multidisciplinary approach to cancer.

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Decision-Making Capacity: The Ethical Core of Patient-Centered Oncology

Who Should Undergo Hereditary Genetic Testing for Cancer?

Tandem CAR T cells targeting mesothelin and MUC16 overcome tumor heterogeneity by targeting one antigen at a time

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